SUBCELLULAR-LOCALIZATION OF INOSITOL LIPID KINASES IN RAT-LIVER
SUBCELLULAR-LOCALIZATION OF INOSITOL LIPID KINASES IN RAT-LIVER
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DOI：
10.1016/0167-4889(85)90173-9
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发表时间：
1985-01-01
期刊：
影响因子：
--
通讯作者：
JUDAH, JD
中科院分区：
文献类型：
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作者：
COCKCROFT, S;TAYLOR, JA;JUDAH, JD
本文研究了磷酸化磷脂酰肌醇生成4-磷酸磷脂酰肌醇和4，5-二磷酸磷脂酰肌醇的酶在大鼠肝脏中的亚细胞分布。虽然磷脂酰肌醇激酶存在于高尔基体、溶酶体和质膜中，但形成磷脂酰肌醇4，5-二磷酸的激酶主要位于质膜上。肌醇脂质激酶在细胞功能中的作用进行了讨论。
The subcellular distribution of the enzymes which phosphorylate phosphatidylinositol sequentially to form phosphatidylinositol 4-phosphate and phosphatidylinositol 4,5-bisphosphate was investigated in rat liver. Whilst phosphatidylinositol kinase is present in golgi, lysosomes and plasma membranes, the kinase that forms phosphatidylinositol 4,5-bisphosphate is localized predominantly at the plasma membrane. The role of the inositol lipid kinases in cell function is discussed.