Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis
Circulating cell adhesion molecules are correlated with ultrasound-based assessment of carotid atherosclerosis
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DOI：
10.1161/01.atv.18.11.1765
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发表时间：
1998-11-01
影响因子：
8.7
通讯作者：
Ridker, PM
中科院分区：
文献类型：
--
作者：
Rohde, LE;Lee, RT;Ridker, PM
尽管细胞黏附分子(CAM)被认为在动脉粥样硬化形成中起重要作用，但其与系统性动脉粥样硬化的关系尚不确定。在92例门诊患者(男性48例，平均年龄+/-SD，65+/-9岁)中，我们评估了可溶性血管细胞黏附分子-1(sVCAM-1)和细胞间黏附分子-1(sICAM-1)与颈动脉内膜-中层厚度(IMT)的关系，IMT是早期动脉粥样硬化的指标。所有受试者都接受了颈总动脉远端和分叉处的双侧颈动脉的二维超声检查。酶联免疫吸附试验检测sVCAM-1和sICAM-1水平与颈总动脉平均IMT显著相关(r=0.34和r=0.30；P
Although cellular adhesion molecules (CAMs) are hypothesized to play an important role in atherogenesis, the relationship between CAMs and systemic atherosclerosis is uncertain. Among 92 outpatients (48 men; mean+/-SD age, 65+/-9 years), we evaluated the association of soluble vascular CAM-1 (sVCAM-1) and intercellular adhesion molecule-1 (sICAM-1) with carotid intimal-medial thickness (IMT), an index of early atherosclerosis. All subjects underwent a 2-dimensional ultrasound examination of both carotid arteries at the distal common carotid arteries and bifurcation. sVCAM-1 and sICAM-1 levels measured by enzyme-linked immunosorbent assay were significantly correlated with mean IMT of the common carotid artery (r=0.34 and r=0.30, respectively; P