Administration of gonadal steroids to the castrated male rat prevents a decrease in the release of gonadotropin-releasing hormone from the incubated hypothalamus.
Administration of gonadal steroids to the castrated male rat prevents a decrease in the release of gonadotropin-releasing hormone from the incubated hypothalamus.
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给阉割的雄性大鼠施用性腺类固醇可防止孵化的下丘脑释放促性腺激素释放激素的减少。
DOI：
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发表时间：
1979
影响因子：
15.9
通讯作者：
P. Snyder
中科院分区：
文献类型：
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作者：
R. Rudenstein;H. Bigdeli;M. H. McDonald;P. Snyder
睾酮对促性腺激素释放激素（GnRH）分泌的影响通过改变雄性大鼠血清睾酮浓度和测量其孵育1周后下丘脑GnRH的释放来间接评估。去势大鼠下丘脑GnRH释放量为13.4+/-1.2 (SE) pg/h，而完整大鼠下丘脑GnRH释放量为35.3+/-3.8 pg/h （P < 0.001）。去势大鼠下丘脑GnRH释放量分别为每天100和500马克杯丙酸睾酮组（25.0+/-3.4 pg/h）和27.9+/-3.6 pg/h (P < 0.05和P < 0.01)，显著高于单纯麻油组（P < 0.05和P < 0.01）。垂体切除大鼠下丘脑GnRH释放的类似减少，以及用丙酸睾酮治疗垂体切除大鼠防止这种减少，证明睾酮的作用不是通过促黄体生成素和（或）促卵泡激素分泌介导的。用丙酸二氢睾酮或苯甲酸雌二醇治疗去势大鼠也能阻止GnRH从去势大鼠下丘脑释放的减少。我们得出结论，睾酮、二氢睾酮和雌二醇都能阻止使用这些类固醇治疗的去势大鼠下丘脑GnRH释放的减少。这些类固醇也可能维持体内GnRH的分泌。
The influence of testosterone on gonadotropin-releasing hormone (GnRH) secretion was assessed indirectly by altering the serum testosterone concentration of male rats and measuring GnRH release from their incubated hypothalami 1 wk later.GnRH release from hypothalami of castrated rats was 13.4+/-1.2 (SE) pg/h, compared to 35.3+/-3.8 pg/h from hypothalami of intact rats (P < 0.001). GnRH release from the hypothalami of castrated rats treated with testosterone propionate, 100 or 500 mug daily, was 25.0+/-3.4 pg/h and 27.9+/-3.6 pg/h, which is significantly greater (P < 0.05 and P < 0.01, respectively) than that from hypothalami of castrated rats treated only with sesame oil.A similar decrease in GnRH release from hypothalami of hypophysectomized rats and prevention of this decrease by treating the hypophysectomized rats with testosterone propionate is evidence that the observed effects of testosterone are not mediated via luteinizing hormone and(or) follicle-stimulating hormone secretion. Treatment of castrated rats with either dihydrotestosterone propionate or estradiol benzoate also prevented the decrease in GnRH release from the hypothalami of castrated rats. We conclude that testosterone, dihydrotestosterone, and estradiol all prevent the decrease in GnRH release from hypothalami of castrated rats treated with these steroids. The possibility exists that these steroids may also maintain GnRH secretion in vivo.