Neuropsychological function in children following admission to paediatric intensive care: a pilot investigation
Neuropsychological function in children following admission to paediatric intensive care: a pilot investigation
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DOI：
10.1007/s00134-008-1093-9
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发表时间：
2008-07-01
影响因子：
38.9
通讯作者：
Garralda, M. Elena
中科院分区：
文献类型：
--
作者：
Elison, Sarah;Shears, Dan;Garralda, M. Elena
目的：对于急性严重儿科疾病后的神经心理学状态知之甚少。这项初步研究探讨了严重急性儿科疾病对记忆功能的影响以及记忆功能与精神后遗症之间的关联。设计和设置：对儿科重症监护病房（PICU）出院后的儿童和健康志愿者进行病例对照研究。患者和参与者：16 名 PICU 出院儿童（包括 11 名男孩和 5 名女孩）（平均年龄 9.44 +/- 2.85 岁）在出院后平均 4.8 +/- 1.4 个月进行了测试，以及 16 名年龄和性别匹配的对照。测量和结果：使用 CANTAB 电池（视觉记忆）评估视觉空间记忆和注意力，使用儿童记忆量表评估言语记忆；智商使用韦克斯勒智力简写量表进行测试。通过优势和困难问卷以及事件影响量表来测量情绪和行为功能。入住儿科重症监护病房的儿童在空间记忆（空间工作记忆）持续注意力（快速视觉信息）和言语记忆（词对学习和延迟识别）测试中表现出统计上较差的表现。脓毒症与 CANTAB 上较差的模式识别记忆特别相关。 PICU 组的认知功能和情绪/行为评分之间存在显着相关性。结论：我们的结果表明，患有急性严重儿科疾病的儿童的记忆力和注意力会受损，患有化脓性疾病的儿童会出现特定的缺陷，并且记忆异常与情绪/行为问题之间存在联系。这些发现及其临床意义需要在更大的样本中进行复制和澄清。
Objective: Little is known about neuropsychological status following acute severe paediatric illness. This pilot study explored the effects on memory function of severe acute paediatric illness and associations between memory functioning and psychiatric sequelae. Design and setting: Case control study of children after paediatric intensive care unit (PICU) discharge and healthy volunteers. Patients and participants: 16 PICU discharged children comprised of 11 boys and 5 girls (mean age 9.44 +/- 2.85 years) tested a mean of 4.8 +/- 1.4 months following hospital discharge, and 16 age- and sex-matched controls. Measurements and results: Visual-spatial memory and attention were assessed using the CANTAB battery (visual memory) and verbal memory with the Children Memory Scale; Intelligence Quotient was tested using the Wechsler Abbreviated Scale of Intelligence. Emotional and behavioural function was measured with the Strengths and Difficulties Questionnaire and Impact of Event Scales. Children admitted to PICU displayed statistically poorer performance on tests of spatial memory (spatial working memory) sustained attention (rapid visual information) and verbal memory (word pairs learning and delayed recognition). Septic illness was specifically associated with poorer pattern recognition memory on the CANTAB. There were significant correlations in the PICU group between cognitive functioning and emotional/behaviour scores. Conclusions: Our results suggest impaired memory and attention in children following acute severe paediatric illness, a specific deficit in children with septic illness and links between memory anomalies and emotional/behavioural problems. The findings and their clinical significance require replication and clarification in a larger sample.