Stress and the kidney.
Stress and the kidney.
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DOI：
10.1053/j.ackd.2014.06.008
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发表时间：
2015-01
影响因子：
2.9
通讯作者：
Thorpe RJ Jr
中科院分区：
文献类型：
--
作者：
Bruce MA;Griffith DM;Thorpe RJ Jr
过去 20 年来，CKD 的患病率大幅增加。慢性肾病（CKD）发病率的上升归因于已知的合并症，如糖尿病、高血压和肥胖；然而，最近的研究已经开始探索社会、经济和心理因素对 CKD 患病率和进展的影响程度，特别是在非裔美国人等高危人群中。有人认为压力可能对慢性肾病有影响，但这一领域的研究在很大程度上尚未得到探索。慢性肾病研究缺乏的一个影响因素是许多社会、心理和环境压力源无法在实验室环境中重现或模拟。社会科学已经证实压力会对健康产生影响，我们相信压力是 CKD 发生和进展的重要决定因素。我们大量借鉴社会科学和社会流行病学文献，提出一个交叉概念框架，详细说明压力如何通过多种压力源和途径对肾脏疾病、其进展及其并发症产生影响。
The prevalence of CKD has increased considerably over the past 2 decades. The rising rates of CKD have been attributed to known comorbidities such as diabetes, hypertension, and obesity; however, recent research has begun to explore the degree to which social, economic, and psychological factors have implications for the prevalence and progression of CKD, especially among high-risk populations such as African Americans. It has been suggested that stress can have implications for CKD, but this area of research has been largely unexplored. One contributing factor associated with the paucity of research on CKD is that many of the social, psychological, and environmental stressors cannot be recreated or simulated in a laboratory setting. Social science has established that stress can have implications for health, and we believe that stress is an important determinant of the development and progression of CKD. We draw heavily from the social scientific and social epidemiologic literature to present an intersectional conceptual frame specifying how stress can have implications for kidney disease, its progression, and its complications through multiple stressors and pathways.