CHANGES IN SAPHENOUS VEINS USED AS AORTOCORONARY BYPASS GRAFTS
CHANGES IN SAPHENOUS VEINS USED AS AORTOCORONARY BYPASS GRAFTS
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DOI：
10.1016/s0002-8703(77)80046-x
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发表时间：
1977-01-01
影响因子：
4.8
通讯作者：
ROBERTS, WC
中科院分区：
文献类型：
--
作者：
SPRAY, TL;ROBERTS, WC
本文描述了隐静脉作为冠状动脉搭桥管道的形态学变化。讨论了各种因素对这些变化的相对贡献。3种主要变化为：中膜纤维替代、外膜纤维增生和内膜纤维增生。内侧纤维替代是由静脉壁缺血伴平滑肌细胞损失引起的;外膜纤维增殖是纤维蛋白沉积组织化和缺血性损伤修复的结果;内膜纤维增殖是由某些刺激引起的，可能是损伤内膜上的纤维蛋白沉积，其导致平滑肌细胞刺激成为成纤维细胞或肌内膜细胞。尽管所有移植物都显示出一些变化，但这3种变化的程度和严重程度在同一患者的不同移植物之间以及沿着移植物的长度沿着是不同的。
Morphologic changes in saphenous veins used as aortocoronary bypass conduits were described. The relative contribution of various factors to these changes were discussed. The 3 primary changes are: medial fibrous replacement, adventitial fibrous proliferation and intimal fibrous proliferation. Medial fibrous replacement is caused by vein wall ischemia with loss of smooth muscle cells; adventitial fibrous proliferation is the result of organization of fibrin deposits and repair of ischemic injury; and intimal fibrous proliferation results from some stimulus, probably fibrin deposition on injured intima, which causes stimulation of smooth muscle cells to become fibroblasts or myointimal cells. Although all grafts show some changes, the degree and severity of these 3 changes is variable along the length of the grafts and among separate grafts in the same patient.