PAX-2 in the Diagnosis of Primary Renal Tumors Immunohistochemical Comparison With Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin
PAX-2 in the Diagnosis of Primary Renal Tumors Immunohistochemical Comparison With Renal Cell Carcinoma Marker Antigen and Kidney-Specific Cadherin
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DOI：
10.1309/ajcpm7dw0xfhdhny
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发表时间：
2009-03-01
影响因子：
3.5
通讯作者：
Truong, Luan D.
中科院分区：
文献类型：
--
作者：
Ozcan, Ayhan;Zhai, Jim;Truong, Luan D.
肾细胞癌（RCC）的诊断仍然存在问题，特别是在转移或小针活检标本的背景下。肾细胞癌标志物（RCCM）和肾特异性钙粘蛋白（KSC）被认为是RCC的特异性标志物，但在低级别RCC的特定亚型中优先表达。本研究旨在评估PAX-2在肾脏肿瘤诊断中的价值，并与RCCM和KSC进行比较。对130例肾肿瘤连续组织切片进行PAX-2、RCCM和KSC免疫染色。PAX-2在常规组织标本中检测成功。尽管PAX-2似乎比RCCM和KSC更敏感，但与组织学亚型相关的染色有明显的重叠，这证明了所有3种标记物的使用是合理的，这有助于检测绝大多数肾脏肿瘤。PAX-2似乎在肾脏新生中起着重要作用，可能是一种新的治疗靶点。
The diagnosis of renal cell carcinoma (RCC) remains problematic, especially in the context of metastasis or small needle biopsy specimens. The renal cell carcinoma marker (RCCM) and kidney-specific cadherin (KSC) are considered specific markers for RCC but are expressed preferentially in specific subtypes of RCC of lower grades. This study was aimed at evaluating the usefulness of PAX-2 in the diagnosis of renal tumors and comparing it with that of RCCM and KSC. Immunostaining for PAX-2, RCCM, and KSC was performed on consecutive tissue sections of 130 renal tumors.PAX-2 was successfully detected in routine tissue specimens. Although PAX-2 seems to be more sensitive than RCCM and KSC, there is significant staining overlap in relation to histologic subtypes, justifying the use of all 3 markers, which helps detect the vast majority of renal neoplasms. PAX-2 seems to have a significant role in renal neogenesis and may represent a novel therapeutic target.