Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men
Resistance Training Increases Skeletal Muscle Capillarization in Healthy Older Men
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DOI：
10.1249/mss.0000000000001019
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发表时间：
2016-11-01
期刊：
影响因子：
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通讯作者：
Van Loon, Luc J. C.
中科院分区：
文献类型：
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作者：
Verdijk, Lex B.;Snijders, Tim;Van Loon, Luc J. C.
目的骨骼肌毛细血管在向肌肉输送氧气和营养物质方面起着关键作用。随着年龄的增长，肌肉质量的减少和合成代谢抵抗的概念至少部分归因于骨骼肌毛细血管结构和功能的变化。我们的目的是比较年轻男性和老年男性的骨骼肌毛细血管化，并评估阻力型运动训练是否增加了老年男性的肌肉毛细血管化。方法取健康青年(n=14，26.2岁)和老年(n=16，72.1岁)成年男性股外侧肌，在12wk阻力型运动训练前和12wk后，对老年人进行肌肉活检。结果老年组II型肌纤维体积小于青年组(4507+/-268vs6084+/-497m(2)，P=0.007)。老年组I型和II型肌纤维CC和CFPE指数均小于青年组(CC I型：3.8±-0.2比5.0+/-0.3；CC II：3.2+/-0.2比4.2+/-0.2，P均为0.001)。阻力型运动训练仅增加II型肌纤维大小。此外，经过12wk抗阻训练后，老年男性I型肌纤维(26%+/-9%和27%+/-8%)和II型肌纤维(33%+/-7%和24%+/-6%；均P<0.001)的CC和CFPE指数均增加。在旨在支持健康老龄化的生活方式干预期间，更多的毛细血管供应可能是逆转合成代谢抵抗和支持肌肉肥大的重要先决条件。
Purpose Skeletal muscle capillarization plays a key role in oxygen and nutrient delivery to muscle. The loss of muscle mass with aging and the concept of anabolic resistance have been, at least partly, attributed to changes in skeletal muscle capillary structure and function. We aimed to compare skeletal muscle capillarization between young and older men and evaluate whether resistance-type exercise training increases muscle capillarization in older men.Methods Muscle biopsies were obtained from the vastus lateralis of healthy young (n = 14, 26 2 yr) and older (n = 16, 72 1 yr) adult men, with biopsies before and after 12 wk of resistance-type exercise training in the older subjects. Immunohistochemistry was used to assess skeletal muscle fiber size, capillary contacts (CC) per muscle fiber, and the capillary-to-fiber perimeter exchange (CFPE) index in type I and II muscle fibers.Results Type II muscle fibers were smaller in old versus young (4507 +/- 268 vs 6084 +/- 497 m(2), respectively, P = 0.007). Type I and type II muscle fiber CC and CFPE index were smaller in old compared with young muscle (CC type I: 3.8 +/- 0.2 vs 5.0 +/- 0.3; CC type II: 3.2 +/- 0.2 vs 4.2 +/- 0.2, respectively; both P < 0.001). Resistance-type exercise training increased type II muscle fiber size only. In addition, CC and CFPE index increased in both the type I (26% +/- 9% and 27% +/- 8%) and type II muscle fibers (33% +/- 7% and 24% +/- 6%, respectively; all P 0.001) after 12 wk resistance training in older men.Conclusions We conclude that resistance-type exercise training can effectively augment skeletal muscle fiber capillarization in older men. The greater capillary supply may be an important prerequisite to reverse anabolic resistance and support muscle hypertrophy during lifestyle interventions aiming to support healthy aging.