Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report.
Cerebrovascular response in infants and young children following severe traumatic brain injury: a preliminary report.
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DOI：
10.1159/000121192
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发表时间：
1997-04
影响因子：
0.7
通讯作者：
David P. Adelson;B. Clyde;P. Kochanek;S. Wisniewski;D. Marion;H. Yonas
中科院分区：
文献类型：
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作者：
David P. Adelson;B. Clyde;P. Kochanek;S. Wisniewski;D. Marion;H. Yonas
为了进一步描述婴幼儿严重创伤性脑损伤（TBI）后的病理生理过程，我们回顾性分析了30名儿童的脑血流量（CBF）值和6个月格拉斯哥结局评分（GOS），70 ml/100 g/min倾向于与良好结局相关。不良结局（GOS或≥ 24个月）。平均CO2 VR为2.1+/-0.6%/PaCO2，范围为0.02 - 5.98%。结果良好和不良儿童的平均CO2 VR往往不同（分别为3.2+/-0.9和1.17+/-0.2%），CO2 VR <或= 2%与不良结果显著相关。年龄较小、TBI后早期CBF较低、CO2 VR <2%与该亚组儿童的不良结局相关。幼儿（<24个月）可能代表严重TBI后早期灌注不足的特殊高危人群。这一发现可能是该年龄组的病理生理学和结局的关键因素，可能需要在我们未来的治疗方案中加以解决。
To further describe the pathophysiologic processes that occur in infants and young children after severe traumatic brain injury (TBI), we retrospectively reviewed the cerebral blood flow (CBF) values and 6-month Glasgow Outcome Scores (GOS) in 30 children 70 ml/100 g/min tended to be associated with a good outcome. Poor outcome (GOS or = 24 months old. Mean CO2VR was 2.1+/-0.6%/torr PaCO2 and ranged from 0.02 to 5.98%. Mean CO2VR tended to differ between good and poor outcome children (3.2+/-0.9 and 1.17+/-0.2%, respectively) and a CO2VR of < or = 2% was significantly associated with a poor outcome. Younger age, low CBF in the early period after TBI, and a CO2VR of <2% was associated with a poor outcome in this subgroup of children. Young children (<24 months) may represent a particular high-risk group with early hypoperfusion after severe TBI. This finding may be a key factor in the pathophysiology and outcome in this age group, and may need to be addressed in our future therapeutic protocols.