Adiponectin, total antioxidant status, and urine albumin excretion in the low-risk "Golden Years" type 1 diabetes mellitus cohort
Adiponectin, total antioxidant status, and urine albumin excretion in the low-risk "Golden Years" type 1 diabetes mellitus cohort
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DOI：
10.1016/j.metabol.2009.12.008
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发表时间：
2011-02-01
影响因子：
9.8
通讯作者：
Stephens, Jeffrey W.
中科院分区：
文献类型：
--
作者：
Prior, Sarah Lyn;Tang, Ting Seng;Stephens, Jeffrey W.
脂联素与炎症和氧化应激有关。2型糖尿病和冠心病患者的血肌酐水平降低。相反，在1型糖尿病（T1 DM）中水平升高，并与微量白蛋白尿和糖尿病肾病相关。一种解释可能是T1 DM中脂联素升高代表了对疾病的有益的反调节反应。我们的目的是检查脂联素与长期T1 DM受试者尿白蛋白排泄和血浆总抗氧化状态（TAOS）的关系。对338例老年人血清脂联素和血浆TAOS进行了检测。这些受试者患有T1 DM至少50年，并发症风险较低。受试者分为正常白蛋白尿、微量白蛋白尿和大量白蛋白尿组。女性的脂联素水平升高（20.53 ± 5.94 vs 11.8 ± 3.6 mg/L，P
Adiponectin is associated with inflammation and oxidative stress. Levels are reduced in type 2 diabetes mellitus and coronary heart disease. Conversely, levels are elevated in type 1 diabetes mellitus (T1DM) and associated with microalbuminuria and diabetic nephropathy. An explanation may be that elevated adiponectin in T1DM represents a beneficial counterregulatory response to disease. Our aim was to examine adiponectin in relation to urinary albumin excretion and plasma total antioxidant status (TAOS) in subjects with long-standing T1DM. Serum adiponectin and plasma TAOS were measured in 338 samples from the Golden Years cohort. These subjects have T1DM for at least 50 years and are at low risk of complications. Subjects were divided into normoalbuminuria, microalbuminuria, and macroalbuminuria groups. Adiponectin was elevated in women (20.53 +/- 5.94 vs 11.8 +/- 3.6 mg/L, P