Oral Crohn Disease -: Clinical characteristics and long-term follow-up of 9 cases
Oral Crohn Disease -: Clinical characteristics and long-term follow-up of 9 cases
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DOI：
10.1001/archderm.135.4.439
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发表时间：
1999-04-01
影响因子：
--
通讯作者：
Cosnes, A
中科院分区：
文献类型：
--
作者：
Dupuy, A;Cosnes, J;Cosnes, A
背景：口腔局限性克罗恩病不常见，必须与非特异性病变鉴别。其自然病程和长期预后尚不清楚。观察：我们研究了9例克罗恩病患者（8名男性，1名女性，年龄范围7-52岁，中位年龄16岁）和特定的口腔病变，包括深线状溃疡，假性息肉，和/或唇或口腔肿胀和硬化。此类病变的发生率为0.5%。中位随访时间为11年。口腔定位在消化道疾病发病前（n = 2）、发病时（n = 2）、发病后（n = 5）发生。在肛门（n = 8）和食管（n = 3）观察到明显的相关定位。口腔病变的中位持续时间为4年（范围1-13年），与消化道定位没有必要的平行性。5例患者在中位延迟2年后完全愈合。结论：口腔克罗恩病的特点是男性明显占优势，克罗恩病发病年龄小，病程长。高患病率的相关肛门和食管累及提示克罗恩病有一个特殊的营养鳞状细胞上皮。
Background: Oral localization of Crohn disease is uncommon and must be differentiated from nonspecific lesions. Its natural course and its long-term prognosis are unknown.Observations: We studied 9 patients (8 male, 1 female; age range, 7-52 years; median age, 16 years) with Crohn disease and specific oral lesions, including deep linear ulcers, pseudopolyps, and/or labial or buccal swelling and induration. The prevalence of such lesions was 0.5%. The median follow-up was 11 years. Oral localization developed before (n = 2), at the same time as (n = 2), or after (n = 5) the onset of the digestive disease. Noticeable associated localizations were observed in the anoperineum (n = 8) and the esophagus (n = 3). The median duration of the oral lesions was 4 years (range, 1-13 years), without necessary parallelism with the digestive localization. Five patients had complete healing after a median delay of 2 years.Conclusions: Oral localization of Crohn disease is characterized by a marked male predominance, a young age at onset of Crohn disease, and a very protracted course. The high prevalence of associated anal and esophageal involvement suggests that Crohn lesions have a particular trophicity for squamous cell epithelium.