Oncogenic Role of Engrailed-2 (En-2) in Prostate Cancer Cell Growth and Survival
Oncogenic Role of Engrailed-2 (En-2) in Prostate Cancer Cell Growth and Survival
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Engrailed-2 (En-2) 在前列腺癌细胞生长和存活中的致癌作用
DOI：
10.4137/tog.s369
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发表时间：
2008
期刊：
影响因子：
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通讯作者：
C. Donald
中科院分区：
文献类型：
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作者：
S. Bose;Rebecca S. Bullard;C. Donald
前列腺癌是美国男性癌症死亡的第二大原因。然而，该疾病的分子机制仍然很大程度上未知。因此，作为开发新的癌症药物的靶标的肿瘤特异性分子的鉴定被认为是癌症研究中的主要目标。小鼠Engrailed-2（En-2）基因是一种含有同源框的转录因子，最近被鉴定为乳腺癌的候选癌基因。在这里，我们证明了En-2在人前列腺癌细胞中过表达，与正常前列腺上皮细胞相比。此外，我们的数据表明，EN 2的表达可能是积极的PAX 2转录因子的调节。此外，通过siRNA下调EN 2表达导致PAX 2表达减少。我们还提供了证据表明，下调EN 2表达导致前列腺癌细胞增殖显着下降。因此，从我们的研究中，我们得出结论，En-2是前列腺癌的候选癌基因，其PAX 2调节的表达有助于前列腺癌细胞的生长。
Prostate cancer is the second leading cause of cancer death among men in the United States of America. However, the molecular mechanisms underlying the disease remain largely unknown. Therefore, the identification of tumor specific molecules that serve as targets for the development of new cancer drugs is considered to be a major goal in cancer research. The mouse Engrailed-2 (En-2) gene, which is a homeobox-containing transcription factor was recently identified as a candidate oncogene in breast cancer. Here, we demonstrate that En-2 is over-expressed in human prostate cancer cells as compared to normal prostate epithelial cells. In addition, our data suggests that EN2 expression may be positively modulated by PAX2 transcription factor. Furthermore, down-regulation of EN2 expression by siRNA resulted in a decrease in PAX2 expression. We also provide evidence that down-regulation of EN2 expression causes a dramatic decrease in prostate cancer cell proliferation. Therefore, from our studies we conclude that En-2 is a candidate oncogene in prostate cancer and its PAX2-regulated expression contributes to prostate cancer cell growth.
乳腺癌和前列腺癌生物标志物的评估。
DOI：
--
发表时间：
1994
期刊：
Journal of cellular biochemistry. Supplement
影响因子：
--
作者：
Grizzle,WE;Myers,RB;Arnold,MM;Srivastava,S
通讯作者：
Srivastava,S