Suppression of arthritis by an inhibitor of nitric oxide synthase.
Suppression of arthritis by an inhibitor of nitric oxide synthase.
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DOI：
10.1084/jem.178.2.749
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发表时间：
1993-08-01
期刊：
影响因子：
--
通讯作者：
Wahl SM
中科院分区：
文献类型：
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作者：
McCartney-Francis N;Allen JB;Mizel DE;Albina JE;Xie QW;Nathan CF;Wahl SM
一氧化氮 (NO) 是一氧化氮合酶 (NOS) 代谢 L-精氨酸过程中产生的有毒自由基气体，被认为是免疫和炎症反应的介质。单次注射链球菌细胞壁碎片 (SCW) 会诱导滑膜组织内炎症细胞的积累和细胞介导的免疫反应，从而导致破坏性病变。我们在此表明，经 SCW 治疗的大鼠发炎关节中 NO 的产生量有所增加。 NG-单甲基-L-精氨酸（一种 NOS 抑制剂）的给药可显着减少滑膜炎症和组织损伤（通过关节指数测量并反映在组织病理学中）。这些研究表明 NO 通路与炎症性关节炎的发病机制有关，并证明了 NOS 抑制剂调节疾病的能力。
Nitric oxide (NO), a toxic radical gas produced during the metabolism of L-arginine by NO synthase (NOS), has been implicated as a mediator of immune and inflammatory responses. A single injection of streptococcal cell wall fragments (SCW) induces the accumulation of inflammatory cells within the synovial tissue and a cell-mediated immune response that leads destructive lesions. We show here that NO production is elevated in the inflamed joints of SCW-treated rats. Administration of NG-monomethyl-L-arginine, an inhibitor of NOS, profoundly reduced the synovial inflammation and tissue damage as measured by an articular index and reflected in the histopathology. These studies implicate the NO pathway in the pathogenesis of an inflammatory arthritis and demonstrate the ability of a NOS inhibitor to modulate the disease.