Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus
Cord blood nesfatin-1 and apelin-36 levels in gestational diabetes mellitus
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DOI：
10.1007/s12020-011-9577-8
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发表时间：
2012-06-01
期刊：
影响因子：
3.7
通讯作者：
Aydin, Suleyman
中科院分区：
文献类型：
--
作者：
Aslan, Mehmet;Celik, Onder;Aydin, Suleyman
探讨妊娠期糖尿病(GDM)孕妇和非妊娠期糖尿病(GDM)孕妇血清和脐血Apelin-36、Nesfatin-1水平。30名妊娠期糖尿病孕妇和30名胎龄匹配的健康孕妇参与了这项研究。采用双抗体夹心法测定出生时孕妇血清和脐带血中Nesfatin-1和Apelin-36的水平。还评估了母体血清和脐带血Nesfatin-1和Apelin-36水平、人体测量和代谢参数之间的关系。妊娠期糖尿病组孕妇血清apelin-36水平高于对照组(13.5+/-A8.3 vs.9.6+/-A5.9 ng/ml，P=0.001)，而Nesfatin-1水平低于对照组(5.5+/-A8.1vs.8.1+/-A23.9 ng/ml，P=0.001)。而脐血apelin-36水平(8.80+/-A4.3和8.2+/-A1.9 ng/ml，P=0.618)和Nesfatin-1水平(5.4+/-A4.0和6.2+/-A10.3 ng/ml，P=0.688)在妊娠期糖尿病组和对照组之间差异无统计学意义。孕妇血清Apelin-36和Nesfatin-1水平与其各自的脐血水平呈正相关。孕妇血清和脐血apelin-36水平与胎龄、出生体重呈负相关。同样，孕妇血清和脐带血Nesfatin-1水平与胎龄呈负相关，但与出生体重无相关性。我们没有发现母体血清apelin-36和Nesfatin-1水平、母体年龄、BMI、空腹血糖、空腹胰岛素和HOMA-IR之间的相关性。此外，脐带血apelin-36和nesifatin-1水平与母亲年龄、BMI、HOMA-IR、脐带血血糖和脐带血胰岛素水平无关。结果表明，妊娠期糖尿病患者外周血中Apelin-36浓度升高，Nesfatin-1浓度下降。
To assess maternal serum and cord blood apelin-36 and nesfatin-1 concentrations in pregnant women with and without gestational diabetes mellitus (GDM). Thirty pregnant women with GDM and 30 gestational age matched healthy pregnant subjects participated to the study. Maternal serum and cord blood nesfatin-1 and apelin-36 levels were measured with ELISA, at the time of birth. The relationships between maternal serum and cord blood nesfatin-1 and apelin-36 levels, anthropometric and metabolic parameters were also assessed. Maternal serum apelin-36 levels were found higher (13.5 +/- A 8.3 vs. 9.6 +/- A 5.9 ng/ml, P = 0.001) and nesfatin-1 levels were found lower (5.5 +/- A 8.1 vs. 8.1 +/- A 23.9 ng/ml, P = 0.001) in patients with GDM compared with control pregnant women. However, the cord blood apelin-36 levels (8.8 +/- A 4.3 and 8.2 +/- A 1.9 ng/ml, P = 0.618) and nesfatin-1 levels (5.4 +/- A 4.0 and 6.2 +/- A 10.3 ng/ml, P = 0.688) were similar in the GDM and control groups, respectively. Maternal serum apelin-36 and nesfatin-1 levels correlated positively with their respective cord blood levels. Maternal serum and cord blood apelin-36 levels correlated negatively with the gestational age and birth weight. Similarly maternal serum and cord blood nesfatin-1 levels correlated negatively with the gestational age, but there was no correlation with the birth weight. We did not find a correlation between maternal serum apelin-36 and nesfatin-1 levels, maternal age, BMI, fasting glucose, fasting insulin, and HOMA-IR. Also cord blood apelin-36 and nesfatin-1 levels did not correlate with the maternal age, BMI, HOMA-IR, cord blood glucose, and cord blood insulin levels. Our results indicate that apelin-36 concentrations increase and nesfatin-1 concentrations decrease in maternal serum of women with GDM.