Intrahepatic fat, abdominal adipose tissues, and metabolic state: magnetic resonance imaging study
Intrahepatic fat, abdominal adipose tissues, and metabolic state: magnetic resonance imaging study
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DOI：
10.1002/dmrr.2888
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发表时间：
2017-07-01
影响因子：
8
通讯作者：
Shai, Iris
中科院分区：
文献类型：
--
作者：
Meir, Anat Yaskolka;Tene, Lilac;Shai, Iris
背景肝内脂肪（IHF）与腰围（WC）和内脏脂肪组织（VAT）有关，但其与腹部皮下脂肪组织的关系存在争议。虽然IHF >= 5%是脂肪肝的二分定义，但% IHF很少被认为是包括正常范围的连续变量。在这项研究中，我们的目的是评估% IHF与腹部脂肪亚库，胰腺和肾窦脂肪的相关性。方法我们评估了% IHF，腹部脂肪亚库，%胰腺和肾窦脂肪，在中度腹部肥胖的个体中，使用3-特斯拉磁共振成像。结果在275名参与者中，% IHF范围很广（0.01%-50.4%），女性（1.6%）低于男性（7.3%; P <0.001）。在年龄、性别和WC校正模型中，VAT面积（P < .006）与% IHF直接相关，而浅表-皮下脂肪组织比例与% IHF呈负相关（P < .006）。在这些模型中，肾窦脂肪与% IHF呈正相关（P = .005）。在年龄、性别、WC和VAT校正模型中，肝酶、血糖、脂质和炎症生物标志物升高与% IHF增加相关（所有均为P <0.003）。在这些模型中，即使在甘油三酯和chemerin的IHF < 5%的正常范围分层内，相关性也保持稳健（所有P = 0.004）。WC、丙氨酸转氨酶、甘油三酯/高密度脂蛋白胆固醇和胰岛素抵抗稳态模型评估的联合曲线下面积诊断脂肪肝为0.84（95% CI，0.79-0.89）。肝内脂肪作为一个连续变量，可以通过特定的传统参数进行预测，即使在当前的正常范围内，并且部分独立于VAT。
Background Intrahepatic fat (IHF) is best known to associate with waist circumference (WC) and visceral adipose tissue (VAT), but its relation to abdominal subcutaneous adipose tissue is controversial. While IHF >= 5% dichotomously defines fatty liver, % IHF is rarely considered as a continuous variable that includes the normal range. In this study, we aimed to evaluate % IHF association with abdominal fat subdepots, pancreatic, and renal-sinus fats.Methods We evaluated % IHF, abdominal fat subdepots, % pancreatic, and renal-sinus fats, among individuals with moderate abdominal obesity, using 3-Tesla magnetic resonance imaging.Results Among 275 participants, % IHF widely ranged (0.01%-50.4%) and was lower in women (1.6%) than men (7.3%; P < .001). In an age, sex, and WC-adjusted models, VAT area (P < .006) was directly associated with % IHF, while superficial-subcutaneous adipose tissue proportion was inversely associated with % IHF (P < .006). In these models, renal-sinus fat was positively associated with % IHF (P = .005). In an age, sex, WC, and VAT-adjusted models, elevated liver enzymes, glycemic, lipid, and inflammatory biomarkers were associated with increased % IHF (P < .003 for all). In these models, the associations remained robust even within the normal range strata of IHF < 5% for triglycerides and chemerin (P = .004 for all). For the diagnosis of fatty liver, the joint area under the curve of WC, alanine-aminotransferase, triglycerides/high-density lipoprotein cholesterol, and homeostasis model assessment of insulin resistance was 0.84(95% CI, 0.79-0.89).Conclusions Intrahepatic fat is differentially associated with abdominal fat subdepots. Intrahepatic-fat as a continuous variable could be predicted by specific traditional parameters, even within the current normal range, and partially independent of VAT.