Telocytes: facts, speculations and myths (Review article).
Telocytes: facts, speculations and myths (Review article).
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发表时间：
2017
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通讯作者：
V. Aleksandrovych;A. Pasternak;P. Basta;M. Sajewicz;J. Walocha;K. Gil
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文献类型：
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作者：
V. Aleksandrovych;A. Pasternak;P. Basta;M. Sajewicz;J. Walocha;K. Gil
端粒细胞(TC)是一种间质细胞类型，胞体较小，触角状伸展极长。TCs是十年前发现的，具有特殊的形态特征、免疫组织化学和分泌组特征、电生理特性和microRNA表达。此外，它们在基因表达上与其他细胞不同。TCS在许多过程中扮演着重要的角色。显然，它们参与了动态平衡、重塑、再生、修复、胚胎发生、血管生成，甚至肿瘤发生。波佩斯库教授强调，“端粒细胞需要世界”，而且它将在任何时候成为现实。本文综述了TCS在不同器官和系统中的特点，强调它们参与了生理和病理生理过程。
Telocyte (TC) is an interstitial cell type with a small cellular body and extremely long tentacle-like extensions. TCs were discovered a decade ago and have specifc morphological characteristics, immunohistochemical and secretome profiles, electrophysiological properties, microRNA expression. Moreover, they are different in gene expression from other cells. TCs play an important role in plenty of processes. Apparently, they are involved in homeostasis, remodelling, regeneration, repair, embryogenesis, angiogenesis and even tumorigenesis. "Telocytes need the world", was emphasized by Professor Popescu and it will be actual at any time. This review summarizes particular features of TCs in different organs and systems, emphasizing their involvement in physiological and pathophysiological processes.