A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
A requirement for the immediate early gene Zif268 in the expression of late LTP and long-term memories
复制标题
DOI：
10.1038/85138
复制
发表时间：
2001-03-01
影响因子：
25
通讯作者：
Davis, S
中科院分区：
文献类型：
--
作者：
Jones, MW;Errington, ML;Davis, S
海马齿状回中长时程增强（LTP）的诱导与立即早期基因Zif268的快速和稳健的转录相关。我们使用了一个突变小鼠与Zif268有针对性的破坏，以询问这个基因，它编码的锌指转录因子，是否需要为后期LTP的维护和长期记忆的表达。我们发现，而突变小鼠表现出早期的LTP在齿状回，晚期LTP是不存在的，当测量24和48小时后，在自由移动的动物破伤风。在空间和非空间学习任务中，短期记忆保持完整，而在需要长期记忆的测试中表现受损。因此，Zif268对于从短期到长期突触可塑性的过渡和长期记忆的表达是必不可少的。
The induction of long-term potentiation (LTP) in the dentate gyrus of the hippocampus is associated with a rapid and robust transcription of the immediate early gene Zif268. We used a mutant mouse with a targeted disruption of Zif268 to ask whether this gene, which encodes a zinc finger transcription factor, is required for the maintenance of late LTP and for the expression of long-term memory. We show that whereas mutant mice exhibit early LTP in the dentate gyrus, late LTP is absent when measured 24 and 48 hours after tetanus in the freely moving animal. In both spatial and non-spatial learning tasks, short-term memory remained intact, whereas performance was impaired in tests requiring long-term memory. Thus, Zif268 is essential for the transition from short- to long-term synaptic plasticity and for the expression of long-term memories.