Dissociable Connectivity within Human Angular Gyrus and Intraparietal Sulcus: Evidence from Functional and Structural Connectivity
Dissociable Connectivity within Human Angular Gyrus and Intraparietal Sulcus: Evidence from Functional and Structural Connectivity
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DOI：
10.1093/cercor/bhq011
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发表时间：
2010-11-01
期刊：
影响因子：
3.7
通讯作者：
Menon, Vinod
中科院分区：
文献类型：
--
作者：
Uddin, Lucina Q.;Supekar, Kaustubh;Menon, Vinod
顶下小叶（IPL）是人脑中的一个异质性区域，参与视觉空间注意、记忆和数学认知。IPL内分区的连接性特征的详细描述对于准确解释涉及该区域的功能性神经影像学研究至关重要。我们分别研究了功能和结构的连接角回（AG）和顶内沟（IPS）使用概率cytoarchitectonic地图。感兴趣区域（ROI）包括前部和后部AG亚区（PGa、PGp）和3个IPS亚区（hIP 2、hIP 1和hIP 3）。静息状态下的功能连接分析表明，PGa更强烈地联系到基底神经节，腹侧前运动区，腹外侧前额叶皮层，而PGp更强烈地连接到腹内侧前额叶皮层，后扣带回，和腹侧区组成的默认模式网络。最前面的IPS ROI，hIP 2和hIP 1，与腹侧运动前回和额中回相连，而最后面的IPS ROI，hIP 3，显示与纹外视区的连接。此外，hIP 1与神经元连接。纤维束成像使用扩散张量成像显示这些功能连接的区域之间的结构连接。我们的研究结果提供了证据的cytoarchitectonically定义的IPL内的细分功能的异质性，并提供了一个新的框架的合成和解释的任务相关的激活和失活涉及的IPL在认知过程中。
The inferior parietal lobule (IPL) of the human brain is a heterogeneous region involved in visuospatial attention, memory, and mathematical cognition. Detailed description of connectivity profiles of subdivisions within the IPL is critical for accurate interpretation of functional neuroimaging studies involving this region. We separately examined functional and structural connectivity of the angular gyrus (AG) and the intraparietal sulcus (IPS) using probabilistic cytoarchitectonic maps. Regions-of-interest (ROIs) included anterior and posterior AG subregions (PGa, PGp) and 3 IPS subregions (hIP2, hIP1, and hIP3). Resting-state functional connectivity analyses showed that PGa was more strongly linked to basal ganglia, ventral premotor areas, and ventrolateral prefrontal cortex, while PGp was more strongly connected with ventromedial prefrontal cortex, posterior cingulate, and hippocampus-regions comprising the default mode network. The anterior-most IPS ROIs, hIP2 and hIP1, were linked with ventral premotor and middle frontal gyrus, while the posterior-most IPS ROI, hIP3, showed connectivity with extrastriate visual areas. In addition, hIP1 was connected with the insula. Tractography using diffusion tensor imaging revealed structural connectivity between most of these functionally connected regions. Our findings provide evidence for functional heterogeneity of cytoarchitectonically defined subdivisions within IPL and offer a novel framework for synthesis and interpretation of the task-related activations and deactivations involving the IPL during cognition.