Treatment of experimental Pneumocystis carinii pneumonia with analogs of pentamidine.
Treatment of experimental Pneumocystis carinii pneumonia with analogs of pentamidine.
复制标题
用喷他脒类似物治疗实验性卡氏肺孢子虫肺炎。
DOI：
10.1111/j.1550-7408.1989.tb02711.x
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Hall,JE
中科院分区：
文献类型：
--
作者：
Tidwell,RR;Kilgore,SG;Ohemeng,KA;Geratz,JD;Hall,JE
Seven analogs of pentamidine were tested for their activity against an immunosuppressed rat model ofPneumocystis cariniipneumonia. Structural alterations of the pentamidine molecule included variations of the alkyl chain linking the two p‐amidino phenoxy moieties and relocation of the amidine groups from the para to the meta position on the phenoxy rings. All analogs of pentamidine were active againstP. cariniipneumonia when compared to a saline‐treated control group. One derivative, 1, 4‐di(4′‐amidinophenoxyJbutane, proved to be statistically more active than the parent drug.
