Possible Mechanisms of Tau Spread and Toxicity in Alzheimer's Disease.
Possible Mechanisms of Tau Spread and Toxicity in Alzheimer's Disease.
复制标题
Tau 蛋白扩散和毒性在阿尔茨海默病中的可能机制
DOI：
10.3389/fcell.2021.707268
复制
发表时间：
2021
影响因子：
5.5
通讯作者：
Li H
中科院分区：
文献类型：
--
作者：
Zhang H;Cao Y;Ma L;Wei Y;Li H
Tau是一种与微管（MT）结合并促进其组装和稳定性的蛋白质。在tau蛋白病中，该蛋白失去了结合MT的能力，并且分离的tau蛋白可以错误折叠并诱导表征阿尔茨海默病（AD）的病理变化。越来越多的证据表明，tau蛋白病可以在细胞或相连的区域之间传播。AD和其他tau蛋白病患者脑中的病理性tau蛋白传递是由于各种tau蛋白种类以“朊病毒样”方式沿沿着神经解剖学连接的区域扩散。这个复杂的过程涉及分泌、细胞摄取、跨细胞转移和/或接种的多个步骤，但tau病理学传播的精确机制仍不清楚。这篇综述总结了目前的证据的性质繁殖的tau物种和可能的步骤涉及的过程中的tau病理传播，包括脱离MT，降解和分泌，并讨论了不同的机制下的tau病理传播。
Tau is a protein that associates with microtubules (MTs) and promotes their assembly and stability. The protein loses its ability to bind MTs in tauopathies, and detached tau can misfold and induce the pathological changes that characterize Alzheimer’s disease (AD). A growing body of evidence indicates that tauopathies can spread between cells or connected regions. Pathological tau transmission in the brain of patients with AD and other tauopathies is due to the spread of various tau species along neuroanatomically connected regions in a “prion-like” manner. This complex process involves multiple steps of secretion, cellular uptake, transcellular transfer, and/or seeding, but the precise mechanisms of tau pathology propagation remain unclear. This review summarizes the current evidence on the nature of propagative tau species and the possible steps involved in the process of tau pathology spread, including detachment from MTs, degradations, and secretion, and discusses the different mechanisms underlying the spread of tau pathology.
登录
查看更多内容
DOI：
10.1073/pnas.94.1.298
发表时间：
1997-01-07
影响因子：
11.1
作者：
Alonso, AD;GrundkeIqbal, I;Iqbal, K
通讯作者：
Iqbal, K
影响因子：
82.9
作者：
Alonso, AD;GrundkeIqbal, I;Iqbal, K
通讯作者：
Iqbal, K
影响因子：
8.8
作者：
Calafate, Sara;Buist, Arjan;Moechars, Diederik
通讯作者：
Moechars, Diederik
Map2和Tau沿微管原丝的外脊纵向结合。
影响因子：
7.8
作者：
Al-Bassam, Jawdat;Ozer, Rachel S;Safer, Daniel;Halpain, Shelley;Milligan, Ronald A
通讯作者：
Milligan, Ronald A
影响因子：
25
作者：
Asai H;Ikezu S;Tsunoda S;Medalla M;Luebke J;Haydar T;Wolozin B;Butovsky O;Kügler S;Ikezu T
通讯作者：
Ikezu T