An improved electrical impedance myography (EIM) tongue array for use in clinical trials.
An improved electrical impedance myography (EIM) tongue array for use in clinical trials.
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DOI：
10.1016/j.clinph.2015.06.021
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Rutkove SB
中科院分区：
文献类型：
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作者：
McIlduff C;Yim S;Pacheck A;Geisbush T;Mijailovic A;Rutkove SB
舌头的电阻抗肌电图（EIM）测量可以提供有关肌萎缩侧索硬化症（ALS）延髓功能障碍的有价值的信息。原型压舌器 EIM 阵列产生呕吐反射。本研究的目的是确定使用较小电极阵列进行舌 EIM 测量的可靠性、平均相位值和耐受性。对总共 31 名健康个体和 4 名患有舌异常的神经肌肉患者进行了舌 EIM 测量。除了执行 Bland-Altman 分析之外，还通过计算组内相关系数 (ICC) 和百分比差异来评估可靠性。还确定了标准描述性统计数据，包括曼-惠特尼检验的结果。在 50 kHz 频率下，评估者内部和评估者间可靠性的 ICC 分别为 0.76（差异 5.17%）和 0.78（差异 5.34%）。健康参与者 (11.61° ± 1.00°) 和患者 (9.87° ± 1.28°) 的平均 EIM 相位值显着不同 (p = 0.0051)。没有参与者出现呕吐反射或不适。小舌头阵列提供了良好的评估者间和评估者内可靠性，可以初步区分健康和患病肌肉，并且耐受性良好。使用较小的 EIM 阵列可以更轻松地获得有关舌头健康的生物标记信息。
Electrical impedance myography (EIM) measurements of the tongue could provide valuable information about bulbar dysfunction in amyotrophic lateral sclerosis (ALS). A prototype tongue depressor EIM array produced gag reflexes. The objectives of this study were to determine the reliability, mean phase values, and tolerability of tongue EIM measurements using a smaller electrode array. Tongue EIM measurements were performed in a total of 31 healthy individuals and four neuromuscular patients with lingual abnormalities. Reliability was assessed by calculating the intraclass correlation coefficient (ICC) and percent difference in addition to performing Bland–Altman analyses. Standard descriptive statistics, including results of a Mann–Whitney test, were also determined. At the 50 kHz frequency, the ICCs for intra- and inter-rater reliability were 0.76 with 5.17% difference and 0.78 with 5.34% difference respectively. The mean EIM phase values of healthy participants (11.61° ± 1.00°) and patients (9.87° ± 1.28°) were significantly different (p = 0.0051). None of the participants experienced gag reflexes or discomfort. The small tongue array provided good inter- and intra-rater reliability, could preliminarily distinguish between healthy and diseased muscle, and was well-tolerated. Biomarker information about tongue health could be more comfortably obtained with a smaller EIM array.