Rapid and Selective Oxidation of Alcohols in Deep Eutectic Solvent
Rapid and Selective Oxidation of Alcohols in Deep Eutectic Solvent
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DOI：
10.1021/ie502019z
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发表时间：
2014-10-08
影响因子：
4.2
通讯作者：
Alipour, Masoumeh
中科院分区：
文献类型：
--
作者：
Azizi, Najmedin;Khajeh, Meysam;Alipour, Masoumeh
低共熔溶剂 (DES) 已被认为是一种高效的催化剂和反应介质，可使用 N-溴代琥珀酰亚胺作为氧化剂将醇快速氧化为醛和酮。这种温和的程序利用可生物降解且易于获得的氯化胆碱/尿素基 DES，在室温或 60 摄氏度下进行高产率氧化。可以在伯醇存在下实现仲醇的选择性氧化。此外，通过DES介导的乙醇串联氧化和溴化实现了2-溴苯乙酮的无催化剂合成。
Deep eutectic solvent (DES) has been identified as a highly efficient catalyst and reaction medium, for rapid oxidation of alcohols to aldehydes and ketones using N-bromosuccinimide as the oxidant. This mild procedure utilizes biodegradable and readily available choline chloride/urea-based DES for high-yield oxidation at room temperature or at 60 degrees C. Selective oxidation of secondary alcohols in the presence of primary alcohols can be achieved. Furthermore, the catalyst-free synthesis of 2-bromoacetophenone was achieved through DES-mediated tandem oxidation and bromination of alcohol.