The Role of Liver Cancer Stem Cells in Donor Liver Allocation for Patients With Hepatocellular Carcinoma
The Role of Liver Cancer Stem Cells in Donor Liver Allocation for Patients With Hepatocellular Carcinoma
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肝癌干细胞在肝细胞癌患者供肝分配中的作用
DOI：
10.3810/pgm.2013.11.2709
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发表时间：
2013-11
影响因子：
4.2
通讯作者：
Shusen Zheng
中科院分区：
文献类型：
--
作者：
Jie Zhou;Zhenhua Hu;Zhiwei Li;Pengfei Yu;Jian Wu;Shusen Zheng
摘要肝细胞癌（HCC）患者肝移植的标准主要强调现有肿瘤的大小和数量;然而，标准没有包括肿瘤生物学，这可能是预测患者预后的关键因素。杭州标准已认识到这一问题，该标准考虑了肿瘤组织病理学分级和移植前甲胎蛋白（AFP）水平。然而，无论是组织病理学分级还是AFP水平都不足以准确地代表HCC患者的肿瘤生物学。最近的研究表明，HCC的发展和进展是由具有干细胞特征的肝细胞亚群（癌症干细胞，[CSC]）驱动的。具有分化簇（CD）133+抗原阳性的肝CSC显示出高致瘤能力，并且CD 133+肝癌细胞百分比的增加与血清AFP水平的增加一致。此外，CD 90+细胞的数量随着HCC的致瘤性而增加，并且已经观察到循环CD 90+肝CSC的数量与疾病进展之间呈正相关。由于肝CSC可以使用CD谱检测，并且可以更准确地代表HCC中的肿瘤生物学，因此我们假设具有特定表型的肝CSC可以用于修改杭州标准，从而为考虑进行肝移植的HCC患者开发更准确的预后预测算法提供有价值的指导。我们提供了可靠的证据支持这一假设，并为移植实践中的未来应用提供了建议。
Abstract Previous criteria for liver transplantation in patients with hepatocellular carcinoma (HCC) has predominantly emphasized the size and number of existent tumors; however, criteria have not included tumor biology, which may comprise a critical factor for predicting patient prognosis. This issue has been recognized in the Hangzhou criteria, which take tumor histopathologic grade and pre-transplant α-fetoprotein (AFP) level into consideration. However, neither histopathologic grading nor AFP level are precise enough to adequately represent tumor biology in patients with HCC. Recent research has indicated that the development and progression of HCC are driven by a subpopulation of liver cells with stem cell features (cancer stem cells, [CSCs]). Liver CSCs with cluster of differentiation (CD)133+ antigen positivity show a high tumorigenic capacity, and the increase in the percentage of CD 133+ liver cancer cells is consistent with increased levels of serum AFP. In addition, the number of CD90+ cells increases with the tumorigenicity of HCC, and a positive correlation between the number of circulating CD90+ liver CSCs and disease progression has been observed. As liver CSCs can be detected using the CD profile and could more accurately represent tumor biology in HCC, we hypothesized that liver CSCs with specific phenotypes could be used for modifying the Hangzhou criteria, thereby providing valuable guidance for the development of more accurate prognosis prediction algorithms for patients with HCC being considered for liver transplantation. We provide reliable evidence supporting this hypothesis, and offer proposals for future applications in transplant practice.
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影响因子：
9
作者：
Yang, Lian-Yue;Fang, Feng;Wu, Fan
通讯作者：
Wu, Fan
DOI：
10.1002/hep.26168
发表时间：
2013-04
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Yamashita T;Honda M;Nakamoto Y;Baba M;Nio K;Hara Y;Zeng SS;Hayashi T;Kondo M;Takatori H;Yamashita T;Mizukoshi E;Ikeda H;Zen Y;Takamura H;Wang XW;Kaneko S
通讯作者：
Kaneko S
影响因子：
9
作者：
Nathan, Hari;Schulick, Richard D.;Pawlik, Timothy M.
通讯作者：
Pawlik, Timothy M.
影响因子：
11.2
作者：
Maria W. Smith;Zhaoxia N Yue;G. Geiss;Natalya Y. Sadovnikova;V. Carter;L. Boix;C. Lázaro;G. B. Rosenberg;Roger E Bumgarner;N. Fausto;J. Bruix;M. Katze
通讯作者：
Maria W. Smith;Zhaoxia N Yue;G. Geiss;Natalya Y. Sadovnikova;V. Carter;L. Boix;C. Lázaro;G. B. Rosenberg;Roger E Bumgarner;N. Fausto;J. Bruix;M. Katze
影响因子：
5.2
作者：
Iwatsuki, S;Dvorchik, I;Starzl, TE
通讯作者：
Starzl, TE