The adrenergic innervation of the rat thalamus as revealed by the glyoxylic acid fluorescence method
The adrenergic innervation of the rat thalamus as revealed by the glyoxylic acid fluorescence method
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乙醛酸荧光法揭示大鼠丘脑的肾上腺素能神经支配
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
U. Stenevi
中科院分区：
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作者：
O. Lindvall;A. Björklund;A. Nobin;U. Stenevi
通过最近引入的乙醛酸荧光方法，研究了大鼠丘脑、上丘脑、下丘脑和下丘脑的肾上腺素能神经支配。在根据标准 Falck-Hillarp 甲醛方法处理的标本中，丘脑和邻近区域的许多区域似乎稀疏地受到儿茶酚胺 (CA) 纤维的支配，但在乙醛酸处理的标本中却发现富含此类纤维。此外，乙醛酸方法可以追踪从细胞体到末端的 CA 轴突，并与立体定位损伤相结合，可以建立以下丘脑 CA 系统： 1 蓝斑系统。这些轴突中的大多数在所谓的背侧被盖束中上升，穿过中脑和未定带进入内侧前脑束。从这个束支沿着几条路线追踪，在许多丘脑、后丘脑和顶盖前区域产生广泛的终端系统，最显着的是前核、腹侧和外侧核复合体，以及内侧和外侧膝状体。 2 背侧室周束，构成先前未描述的背侧纵束的肾上腺素能成分。该系统起源于中缝背区、中脑中央灰质和丘脑尾部脑室周围灰质的细胞体（定义为 A11 细胞群）。轴突在背侧纵束内上升，产生丘脑和下丘脑脑室周围系统，投射到丘脑内侧和中线、上丘脑和顶盖前区域。 3 室旁丘脑核的部分末端被识别为桥脑或髓质网状结构中细胞体的非轨迹投影。 4 在丘脑尾部、未定带以及下丘脑背侧和前侧发现了一个精致的、可能含有多巴胺的轴突系统。该系统可能起源于间脑A11和A13细胞群的多巴胺细胞体，形成迄今为止未知的间脑内多巴胺能系统。
The adrenergic innervation of the thalamus, epithalamus, metathalamus, and subthalamus in the rat has been investigated by means of the recently introduced glyoxylic acid fluorescence method. Many areas of the thalamus and adjoining regions, that appear sparsely innervated by catecholamine (CA) fibers in specimens processed according to the standard Falck‐Hillarp formaldehyde method, were found to be richly supplied with such fibres in the glyoxylic acid‐treated specimens. Moreover, the glyoxylic acid method allows the tracing of the CA axons from the cell bodies up to the terminals, and in combination with stereotaxic lesions the following CA systems to the thalamus could be established: 1 The locus coeruleus system. Most of these axons ascend in the so‐called dorsal tegmental bundle through the mesencephalon and the zona incerta into the medial forebrain bundle. From this bundle branches were traced along several routes, giving rise to extensive terminal systems in many thalamic, metathalamic and pretectal areas, most notably the anterior, ventral and lateral nuclear complexes, and the medial and lateral geniculate bodies. 2 The dorsal periventricular bundle, which constitutes a previously not described adrenergic component of the dorsal longitudinal fasciculus. This system originates in cell bodies (defined as the A11 cell group) in the dorsal raphe region, the central gray of the mesencephalon, and in the periventricular gray of the caudal thalamus. The axons ascend within the dorsal longitudinal fasciculus and give rise to a thalamic and hypothalamic periventricular system, projecting to medial and midline thalamic, epithalamic and pretectal regions. 3 Part of the terminals in the paraventricular thalamic nucleus was identified with a non‐locus projection from cell bodies in the pontine or medullary reticular formation. 4 A system of delicate, probably dopamine‐containing axons was revealed in the caudal thalamus, the zona incerta and the dorsal and anterior hypothalamus. This system probably originates in the dopamine cell bodies of the diencephalic A11 and A13 cell groups, forming a hitherto unknown intradiencephalic dopaminergic system.