Poly-4-hydroxybutyrate (P4HB): a new generation of resorbable medical devices for tissue repair and regeneration
Poly-4-hydroxybutyrate (P4HB): a new generation of resorbable medical devices for tissue repair and regeneration
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DOI：
10.1515/bmt-2013-0009
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发表时间：
2013-10-01
影响因子：
1.7
通讯作者：
Martin, David P.
中科院分区：
文献类型：
--
作者：
Williams, Simon F.;Rizk, Said;Martin, David P.
聚 4-羟基丁酸酯 (P4HB) 是一种热塑性线性聚酯，通过重组发酵生产，可转化为各种可吸收医疗器械。 P4HB 纤维非常坚固，可设计为在体内提供长时间的强度保持。 2007 年，FDA 批准了由 P4HB 制成的单丝缝合线，用于一般软组织缝合和/或结扎。随后，用于疝气修复、肌腱和韧带修复以及整形和重建手术的外科网状装置已被引入临床使用。本综述描述了 P4HB 的独特性质、其临床应用以及正在开发的潜在用途。
Poly-4-hydroxybutyrate (P4HB) is a thermoplastic, linear polyester, produced by recombinant fermentation, that can be converted into a wide range of resorbable medical devices. P4HB fibers are exceptionally strong, and can be designed to provide prolonged strength retention in vivo. In 2007, the FDA cleared a monofilament suture made from P4HB for general soft tissue approximation and/or ligation. Subsequently, surgical mesh devices for hernia repair, tendon and ligament repair, and plastic and reconstructive surgery have been introduced for clinical use. This review describes the unique properties of P4HB, its clinical applications, and potential uses that are under development.