Effect of N-acetylcysteine on myocardial infarct size following ischemia and reperfusion in dogs.
Effect of N-acetylcysteine on myocardial infarct size following ischemia and reperfusion in dogs.
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N-乙酰半胱氨酸对狗缺血和再灌注后心肌梗死面积的影响。
DOI：
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发表时间：
1998
影响因子：
--
通讯作者：
B. M. Hegde
中科院分区：
文献类型：
--
作者：
Y. Tripathi;B. M. Hegde
本研究旨在探讨n -乙酰半胱氨酸（NAC）在犬自由基介导的再灌注损伤中的作用。14只狗接受90分钟的左冠状动脉前降支闭塞，然后再灌注4小时。治疗动物在再灌注时给予NAC负荷剂量（250 mg/kg）至1 h，然后通过左心房线给予维持剂量（70 mg/kg）至剩余3 h。在再灌注结束时测量治疗组（n = 7）和未治疗组（n = 7）的梗死面积、心肌组织脂质过氧化、超氧化物歧化酶（SOD）和谷胱甘肽（GSH）水平。治疗组左室舒张末期压明显低于未治疗组。两组心肌危险区和梗死区超氧化物歧化酶和谷胱甘肽水平相似。然而，在NAC处理的动物中，脂质过氧化作用明显低于未处理的对照组动物。危险区域的梗死面积、左心室坏死百分比和心肌组织保存在治疗和未治疗的动物中没有显著差异。这些结果表明，缺血90 min和再灌注4 h后再灌注n -乙酰半胱氨酸不能对自由基损伤提供明显的心脏保护，但可以通过降低预负荷来改善心室功能。
The present study was designed to examine the role of N-acetylcysteine (NAC) on free radical mediated reperfusion injury in canine model. Fourteen dogs underwent 90 min of left anterior descending coronary artery (LAD) occlusion followed by 4 h of reperfusion. Treated animals received loading dose of NAC (250 mg/kg) at the time of reperfusion upto 1 h followed by maintenance dose (70 mg/kg) for remaining 3 h through left atrial line. Infarct size, myocardial tissue lipid peroxidation, superoxide dismutase (SOD) and glutathione (GSH) levels were measured at the end of reperfusion in treated (n = 7) and untreated animals (n = 7). Left ventricular end diastolic pressure was significantly lower in treated animals compared to untreated group. SOD and GSH levels in myocardial tissue at risk and in infarcted zone were similar in both groups. However, in NAC treated animals the lipid peroxidation was significantly lower in comparison to untreated control animals. Infarct size in the area at risk, percent left ventricular necrosis and myocardial tissue preservation were not significantly different in treated and untreated animals. These results suggests that N-acetylcysteine infusion at the time of reperfusion following 90 min of ischemia and 4 h of reperfusion fails to offer significant cardioprotection against free radical damage but it can improve ventricular performance by decreasing pre load.
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影响因子：
37.8
作者：
BLAUSTEIN, A;DENEKE, SM;FANBURG, BL
通讯作者：
FANBURG, BL
维生素 E、抗坏血酸和甘露醇对四氧嘧啶诱导的大鼠脂质过氧化的影响。
影响因子：
3.9
作者：
Dillard,CJ;Kunert,KJ;Tappel,AL
通讯作者：
Tappel,AL
黄嘌呤氧化酶抑制剂别嘌呤醇未能限制狗缺血和再灌注后的梗塞面积。
影响因子：
37.8
作者：
Reimer,KA;Jennings,RB
通讯作者：
Jennings,RB
再灌注和再灌注损伤。
DOI：
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发表时间：
1987
期刊：
Clinical research
影响因子：
--
作者：
Weisfeldt,ML
通讯作者：
Weisfeldt,ML