Compensation and Disease Severity on the Memory-Related Activations in Mild Cognitive Impairment
Compensation and Disease Severity on the Memory-Related Activations in Mild Cognitive Impairment
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DOI：
10.1016/j.biopsych.2010.02.004
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发表时间：
2010-11-15
影响因子：
10.6
通讯作者：
Belleville, Sylvie
中科院分区：
文献类型：
--
作者：
Clement, Francis;Belleville, Sylvie
背景阿尔茨海默病是一种神经退行性疾病，伴有进行性认知障碍，可能会影响患者的补偿机制和大脑激活模式。方法使用功能神经成像来测试疾病严重程度对阿尔茨海默病高危人群大脑激活的影响，并强调其中一些人的补偿过程。这是为了患者的言语学习而进行的将26例轻度认知障碍（MCI）患者分为MCI高认知组和MCI低认知组，Mattis痴呆评定量表评分的中位数一组14名健康老年人与MCI参与者相匹配。结果在两种任务条件下，MCI较高的认知激活了相对于对照受试者的额外区域。右前额叶腹外侧和背外侧脑区在编码语义相关的词对时，在右前额叶45区和编码不相关的词对时，在左海马中发现了额外的超激活区域。相反，与健康对照组相比，MCI低认知者没有显示额外的前额叶激活，并且显示后部区域的激活减少。补偿发生在MCI连续体的开始，并且在经历更严重症状的患者中补偿崩溃
Background Alzheimer's disease is a neurodegenerative disease with progressive cognitive impairments that are likely to affect the compensatory mechanisms and the cerebral activation patterns of the patientsMethods Functional neuroimaging was used to test the effect of disease severity on the brain activation of persons at risk for Alzheimer's disease and to highlight the process of compensation in some of these individuals This was done for the verbal learning of either semantically related or semantically unrelated word pairs Twenty six persons with mild cognitive impairment (MCI) were separated into two groups MCI higher cognition and MCI lower-cognition with a split-median on their scores for the Mattis Dementia Rating Scale A group of 14 healthy older adults were matched to the MCI participantsResults In both task conditions MCI higher cognition activated additional regions relative to control subjects in the right ventrolateral and dorsolateral prefrontal brain areas Additional areas of hyperactivation were found in the right prefrontal area 45 when encoding semantically related word pairs and in the left hippocampus during encoding of unrelated word pairs In contrast MCI lower cognition failed to show additional prefrontal activations when compared with healthy control subjects and showed decreased activation in posterior areasConclusions These results are in line with compensation occurring at the beginning of the MCI continuum and with the breakdown of compensation in patients experiencing more severe symptoms