A central neural circuit for experience-independent olfactory and courtship behavior in Drosophila melanogaster
A central neural circuit for experience-independent olfactory and courtship behavior in Drosophila melanogaster
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DOI：
10.1073/pnas.011314898
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发表时间：
2001-12-18
影响因子：
11.1
通讯作者：
Stocker, RF
中科院分区：
文献类型：
--
作者：
Heimbeck, G;Bugnon, V;Stocker, RF
我们研究了果蝇主要中枢嗅觉通路的功能。这一通路的关键要素，即投射神经元（PNs），直接或间接地将触角叶与外侧前脑连接起来，后者通过蘑菇体（mb）连接。破伤风毒素在大多数PNs和少数MB神经元中的转基因表达导致气味检测和雄性求偶的缺陷。考虑到缺乏mbbs的果蝇的行为数据，我们的研究结果认为，直接的pn -外侧前脑通路对于处理这些经验独立行为是必要和充分的。此外，嗅觉途径在雄性求偶过程中的参与表明，在果蝇中挥发性的有吸引力的雌性信息素的作用。
We have studied the function of the major central olfactory pathway in fruit flies. Key elements of this pathway, the projection neurons (PNs), connect the antennal lobes with the lateral protocerebrum both directly and indirectly, the latter via the mushroom bodies (MBs). Transgenic expression of tetanus toxin in the majority of PNs and few MB neurons leads to defects in odor detection and male courtship. Considering behavioral data from flies lacking MBs, our results argue that the direct PN-to-lateral protocerebrum pathway is necessary and sufficient to process these experience-independent behaviors. Moreover, the involvement of an olfactory pathway in male courtship suggests a role of volatile attractive female pheromones in Drosophila.