Sex differences in regional brain response to aversive pelvic visceral stimuli
Sex differences in regional brain response to aversive pelvic visceral stimuli
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DOI：
10.1152/ajpregu.00065.2006
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发表时间：
2006-08-01
影响因子：
2.8
通讯作者：
Mayer, Emeran A.
中科院分区：
文献类型：
--
作者：
Berman, Steven M.;Naliboff, Bruce D.;Mayer, Emeran A.
为了探索7个脑区对令人厌恶的盆腔内脏刺激的反应的性别差异，研究人员对13名健康成人（6名女性）在两种压力下(25毫米汞柱（不舒服）和45毫米汞柱（轻度疼痛），以及在预期状态下（无膨胀）进行了15秒的直肠膨胀提示成像。随机效应分析结合受试者的体向数据发现，45mmhg压力显著激活了两性的岛叶和前扣带皮层。只有男性的左丘脑和腹侧纹状体也被激活。虽然所有的激活在男性中表现得更广泛，但没有性别差异达到显著性。为了探索失活的存在，当受试者结合每个体素时，通常会被更多的激活所抵消，激活体素的数量、失活体素的数量以及失活体素与受影响的总体素的比例通过随机效应、混合模型分析来评估，并结合区域层面的受试者数据。在预期状态和25毫米汞柱膨胀期间，男性的脑岛活化程度高于女性。在女性中，杏仁核（25毫米汞柱膨胀）和中扣带（45毫米汞柱膨胀）的失活程度更高。在25毫米汞柱膨胀期间，女性在所有四个皮质下结构中失活体素的比例明显高于男性。对女性生理盆腔内脏不适的更熟悉可能会增强大脑系统，在较低程度的不适时抑制唤醒网络。
To explore sex differences in the response of seven brain regions to an aversive pelvic visceral stimulus, functional magnetic resonance images were acquired from 13 healthy adults (6 women) during 15 s of cued rectal distension at two pressures: 25 mmHg (uncomfortable), and 45 mmHg (mild pain), as well as during an expectation condition (no distension). Random effects analyses combining subject data voxelwise found 45-mmHg pressure significantly activated the insular and anterior cingulate cortices in both sexes. In men only, the left thalamus and ventral striatum were also activated. Although all activations appeared more extensive in men, no sex difference attained significance. To explore the presence of deactivations, which are generally cancelled by more numerous activations when subjects are combined for each voxel, the number of activated voxels, number of deactivated voxels, and ratio of deactivated voxels to total voxels affected were assessed via random-effects, mixed-model analyses combining subject data at the region level. Greater insula activation in men compared with women was seen during the expectation condition and during the 25-mmHg distension. Greater deactivations in women were seen in the amygdala (25-mmHg distension) and midcingulate (45-mmHg distension). Women had a significantly higher proportion of deactivated voxels than men in all four subcortical structures during 25-mmHg distension. Greater familiarity of females with physiological pelvic visceral discomfort may have enhanced brain systems that dampen arousal networks during lower levels of discomfort.