Systemic Effects of ADP-induced Platelet Aggregation and Their Modification by Aspirin and by Pyridinolcarbamate
Systemic Effects of ADP-induced Platelet Aggregation and Their Modification by Aspirin and by Pyridinolcarbamate
复制标题
ADP 诱导的血小板聚集的全身效应及其通过阿司匹林和吡啶醇氨基甲酸酯的修饰
DOI：
10.1055/s-0038-1649115
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发表时间：
1973
影响因子：
6.7
通讯作者：
P. Didisheim
中科院分区：
文献类型：
--
作者：
I. Kobayashi;P. Didisheim
小结 ADP、AMP 或 ATP 快速静脉注射至大鼠体内。 ADP注射导致以下短暂变化：血小板计数下降、中心静脉压升高、颈动脉PO2下降、心动过缓、心律失常、扑动颤动和动脉低血压。 AMP 和 ATP 产生了一些相同的效果；但除了低血压外，其发生频率和严重程度均远低于 ADP 治疗后的情况。事先静脉注射乙酰水杨酸或吡啶醇氨基甲酸酯（体外 ADP 诱导的第二波血小板聚集的两种抑制剂）可显着降低除低血压之外的所有上述 ADP 诱导变化的频率和严重程度。这些观察结果表明，注射 ADP 后观察到的许多变化（低血压除外）是由血小板聚集体产生的，血小板聚集体短暂停留在各种微循环床中，然后迅速分解并再循环。
Summary ADP, AMP, or ATP was injected rapidly intravenously in rats. ADP injection resulted in the f olio wing transient changes: a drop in platelet count, a rise in central venous pressure, a fall in carotid arterial PO2, bradycardia, arrhythmia, flutter-fibrillation, and arterial hypotension. AMP and ATP produced some of these same effects; but except for hypotension, their frequency and severity Avere much less than those following ADP. Prior intravenous administration of acetylsalicylic acid or pyridinolcarbamate, two inhibitors of the second wave of ADP-induced platelet aggregation in vitro, significantly reduced the frequency and severity of all the above ADP-induced changes except hypotension. These observations suggest that many of the changes (except hypotension) observed to follow ADP injection are produced by platelet aggregates which lodge transiently in various microcirculatory beds then rapidly disaggregate and recirculate.