miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA
miRNA and mRNA expression profiles in gastric cancer patients and the relationship with circRNA
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DOI：
10.4149/neo_2018_181211n952
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发表时间：
2019-01-01
期刊：
影响因子：
3
通讯作者：
Shen, X. B.
中科院分区：
文献类型：
--
作者：
Jiang, F.;Shen, X. B.
胃癌（GC）是一种全球性的恶性肿瘤，miRNA和mRNA与胃癌的发生密切相关。然而，目前尚不清楚这些分子如何影响GC，以及它们的作用是否与GC患者的circRNA相关。因此，我们从GEO数据库中获得了GC患者的miRNA、mRNA和circRNA表达谱。为了进行比较，通过基因本体论（GO）和途径分析来注释来自微阵列结果的共享miRNA和mRNA。我们还通过TargetScan 7.2鉴定了miRNA靶向的mRNA，通过CircInteractome鉴定了miRNA靶向的circRNA。对微阵列结果的综合分析揭示了72个共有的miRNAs，其中6个miRNAs的表达谱在肿瘤组和对照组之间存在显著差异（倍数变化的绝对值>2，p2，p
Gastric cancer (GC) is a malignant tumor that affects individuals worldwide, and miRNA and mRNA are closely connected to this disease. However, it is still unclear how these molecules affect GC and whether their effects are associated with circRNA in GC patients. Therefore, we obtained the miRNA, mRNA and circRNA expression profiles of GC patients from the GEO database. For comparison, shared miRNAs and mRNAs from the results of microarrays were annotated by gene ontology (GO) and pathway analysis. We also identified mRNAs that were targeted by miRNA through TargetScan 7.2 and circRNAs that were targeted by miRNA through CircInteractome. A comprehensive analysis of the microarray results revealed 72 shared miRNAs, and the expression profiles of 6 miRNAs were significantly different between the tumor and control groups (the absolute value of fold change >2, p2, p