Making Sense of Extracellular Vesicles in Body Fluids: Promise and Challenge.
Making Sense of Extracellular Vesicles in Body Fluids: Promise and Challenge.
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DOI：
10.1093/schbul/sbab009
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发表时间：
2021-03
影响因子：
6.6
通讯作者：
S. Kano;Kun Yang;A. Sawa
中科院分区：
文献类型：
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作者：
S. Kano;Kun Yang;A. Sawa
在他们的新研究中，Du等人分析了来自4个独立队列的385名精神分裂症患者（SZ）和332名健康对照者的血清衍生外泌体。他们发现25种外泌体相关代谢物，如富含甘油磷脂代谢的代谢物，可以作为生物标志物，以非常高的准确性区分SZ患者和对照组。对无药物患者的分析表明，外泌体相关代谢物的变化不受药物的影响。利用外泌体相关蛋白作为区分SZ患者的生物标志物
In their new Du et al analyzed serum-derived exosomes from 385 patients with schizophrenia (SZ) and 332 healthy controls from 4 independent cohorts. They found that 25 exosome-associated metabolites, such as those enriched in glycerophospholipid metabolism, could be utilized as biomarkers to distinguish SZ patients from controls with very high accuracy. The analysis of drug-free patients suggests that the exosome-associated metabolite changes are not affected by medications. the utility of exosome-associated in the as biomarkers to distinguish SZ patients