Vasopressin and oxytocin are depleted from rat hypothalamic nuclei after oral hypertonic saline.
Vasopressin and oxytocin are depleted from rat hypothalamic nuclei after oral hypertonic saline.
复制标题
口服高渗盐水后，大鼠下丘脑核中的加压素和催产素被耗尽。
DOI：
10.1126/science.935863
复制
发表时间：
1976
期刊：
影响因子：
56.9
通讯作者：
J. George
中科院分区：
文献类型：
--
作者：
J. George
口服2%氯化钠代替饮用水3天和10天后，通过放射免疫测定法测量大鼠垂体后叶和显微解剖的下丘脑区域的加压素和催产素。垂体后叶和下丘脑特定区域的两种激素浓度显着下降。高渗盐水后，视上、室旁、弓状下丘脑核和视交叉后区域的一种或两种激素浓度降低，而视交叉上核和正中隆起的激素浓度不受影响。
Vasopressin and oxytocin were measured by radioimmunoassay in rat posterior pituitary and microdissected hypothalamic areas after 3 and 10 days of oral 2 percent sodium chloride in place of drinking water. There was a significant decrease in concentration of both hormones in posterior pituitary and in specific areas of the hypothalamus. Supraoptic, paraventricular, and arcuate hypothalamic nuclei and the retrochiasmatic area had decreased concentration of one or both hormones following hypertonic saline, while hormone concentration in the suprachiasmatic nucleus and median eminence was unaffected.