A New Porous Reaction Layer for Developing Addressable Molecular Libraries
A New Porous Reaction Layer for Developing Addressable Molecular Libraries
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DOI：
10.1021/ja907000m
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发表时间：
2009-11-25
影响因子：
15
通讯作者：
Moeller, Kevin D.
中科院分区：
文献类型：
--
作者：
Hu, Libo;Bartels, Jennifer L.;Moeller, Kevin D.
我测试了一种用于微电极阵列的新型二嵌段共聚物衍生的多孔反应层的稳定性以及与位点选择性合成和电化学信号实验的兼容性。该二嵌段共聚物由用于附着到阵列表面的肉桂酰基取代的聚甲基丙烯酸酯嵌段和用于对阵列中靠近微电极的表面进行选择性功能化的溴取代的聚苯乙烯嵌段组成。位点选择性 Suzuki、Heck 和 Cu(I) 偶联反应均在新反应层上进行，并进行了电化学阻抗研究。
A new diblock copolymer-derived porous reaction Layer for microelectrode arrays has I been tested for its stability and its compatibility with both site-selective synthesis and electrochemical signaling experiments. The diblock copolymer consisted of a cinnamoyl-substituted polymethacrylate block for attachment to the surface of the array and a bromo-substituted polystyrene block for selective functionalization of the surface proximal to microelectrodes in the array. Site-selective Suzuki, Heck, and Cu(I)-coupling reactions were all performed on the new reaction layer along with electrochemical impedance studies.