NMDA receptors in nervous system diseases
NMDA receptors in nervous system diseases
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DOI：
10.1016/j.neuropharm.2013.03.030
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发表时间：
2013-11
影响因子：
4.7
通讯作者：
Qiang Zhou;Morgan Sheng
中科院分区：
文献类型：
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作者：
Qiang Zhou;Morgan Sheng
NMDAR功能障碍已经成为几种主要神经系统疾病的共同主题，包括缺血性脑损伤、慢性神经退行性疾病、疼痛、抑郁和精神分裂症。NMDARs的过度活动或功能减退都可能参与疾病的病理生理过程。NMDAR的不同亚型(由亚单位组成和/或亚突触位置定义)很可能与中枢神经系统疾病有不同的关系。在这里，我们集中在NMDAR贡献相对较好的几个神经系统疾病的例子，并讨论这些疾病的潜在治疗意义。这篇文章是题为《谷氨酸受体依赖的突触可塑性》特刊的一部分。
NMDA receptor (NMDAR) dysfunction has emerged as a common theme in several major nervous system disorders, including ischemic brain injury, chronic neurodegenerative diseases, pain, depression and schizophrenia. Either hyperactivity or hypofunction of NMDARs could contribute to disease pathophysiology. It is likely that distinct subtypes of NMDARs (as defined by subunit composition and/or subsynaptic location) are differentially involved in central nervous system diseases. Here we focus on a few examples of nervous system diseases where the contribution of NMDARs is relatively well characterized and discuss the implications for potential treatment of these illnesses.This article is part of the Special Issue entitled ‘Glutamate Receptor-Dependent Synaptic Plasticity’.