Communicating with the dead: lipids, lipid mediators and extracellular vesicles.
Communicating with the dead: lipids, lipid mediators and extracellular vesicles.
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DOI：
10.1042/bst20160477
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发表时间：
2018-05
影响因子：
3.9
通讯作者：
A. Devitt;H. Griffiths;I. Milic
中科院分区：
文献类型：
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作者：
A. Devitt;H. Griffiths;I. Milic
细胞凋亡是控制炎症的关键事件。然而，为了成功，垂死细胞必须有效地将其存在传达给吞噬细胞，以确保及时清除垂死细胞。在这里，我们考虑凋亡细胞衍生的细胞外囊泡和所包含的脂质和脂质介质的作用，以确保有效控制炎症。我们讨论了细胞死亡和细胞通信研究中的关键问题，并介绍了“活性细胞外囊泡”作为代谢活性和潜在变化的细胞间通信器的概念。
Apoptosis is a key event in the control of inflammation. However, for this to be successful, dying cells must efficiently and effectively communicate their presence to phagocytes to ensure timely removal of dying cells. Here, we consider apoptotic cell-derived extracellular vesicles and the role of contained lipids and lipid mediators in ensuring effective control of inflammation. We discuss key outstanding issues in the study of cell death and cell communication, and introduce the concept of the 'active extracellular vesicle' as a metabolically active and potentially changing intercellular communicator.