Multiple Repetitions Reveal Functionally and Anatomically Distinct Patterns of Hippocampal Activity During Continuous Recognition Memory
Multiple Repetitions Reveal Functionally and Anatomically Distinct Patterns of Hippocampal Activity During Continuous Recognition Memory
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DOI：
10.1002/hipo.20456
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发表时间：
2008-01-01
期刊：
影响因子：
3.5
通讯作者：
Rugg, Michael D.
中科院分区：
文献类型：
--
作者：
Johnson, Jeffrey D.;Muftuler, L. Tugan;Rugg, Michael D.
我们使用连续识别程序，包括多次呈现测试项目以及高分辨率功能磁共振成像（fMRI），以研究项目新颖性与内侧颞叶（MTL）中识别相关活动之间的关系。在海马体和海马旁皮层的几个区域中，新项目引发的活动超过了旧项目的活动，而没有 MTL 区域对旧项目表现出更大的活动。至关重要的是，MTL 的解剖学上不同的区域以两种不同的方式受到项目新颖性的影响，统计上可分离的活动概况证明了这一点。在双侧内侧海马和左后海马旁皮层中，活动遵循分类特征，其中新项目的活动比旧项目的活动更大，但随着旧项目的额外呈现而没有进一步差异。相比之下，对右侧海马体和左侧海马旁皮层相邻区域的影响进行了分级，其中活动相对于每个连续的项目呈现呈线性下降。这些发现表明，海马（和海马旁）活动与连续心理维度（例如项目新颖性）之间的关系无法通过单一函数来捕获。 (C) 2008 Wiley-Liss, Inc.
We used a continuous recognition procedure that included multiple presentations of test items, along with high-resolution functional magnetic resonance imaging (fMRI), to investigate the relationship between item novelty and recognition-related activity in the medial temporal lobe (MTL). In several regions of hippocampus and parahippocampal cortex, activity elicited by new items exceeded that for old items, whereas no MTL regions exhibited greater activity for old items. Critically, anatomically distinct regions of MTL were engaged by item novelty in two different ways, as evidenced by statistically dissociable profiles of activity. In bilateral medial hippocampus and left posterior parahippocampal cortex, activity followed a categorical profile in which it was greater for new than old items but did not differ further with additional presentations of old items. By contrast, effects in adjacent regions of right lateral hippocampus and left parahippocampal cortex were graded, whereby activity declined linearly with respect to each successive item presentation. These findings suggest that the relationship between hippocampal (and parahippocampal) activity and continuous psychological dimensions, such as item novelty, cannot be captured by a unitary function. (C) 2008 Wiley-Liss, Inc.