Abnormal dexamethasone suppression test in primary obsessive-compulsive patients: A confirmatory report
Abnormal dexamethasone suppression test in primary obsessive-compulsive patients: A confirmatory report
复制标题
原发性强迫症患者地塞米松抑制试验异常：证实性报告
DOI：
10.1016/0165-1781(84)90059-3
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发表时间：
1984
影响因子：
11.3
通讯作者：
C. Juenet
中科院分区：
文献类型：
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作者：
J. Cottraux;M. Bouvard;B. Claustrat;C. Juenet
对 20 名符合 DSM-III 强迫症 (OCD) 标准的患者（10 名男性，10 名女性）进行基线皮质醇测量后进行地塞米松抑制试验 (DST)。六名患者（30%）表现出对地塞米松抑制的异常逃避。 DST 抑制者与 DST 非抑制者在年龄、继发性抑郁症发生率或汉密尔顿抑郁评定量表、明尼苏达多相人格量表 D 量表或强迫症评定量表上的得分没有差异。令人惊讶的是，抑制者有更严重的抑郁症家族史，而非抑制者则有过多的男性受试者。此外，夏令时前后的皮质醇水平之间存在显着相关性。在六名非抑制者中，有五名患者的抑郁症状和强迫行为对抗抑郁治疗（其中一名患者还结合了强化行为治疗）的反应均有所减弱。讨论了强迫症和内源性抑郁症之间的关系，以及 DST 的特异性。
The dexamethasone suppression test (DST) was administered after baseline cortisol measurements in 20 patients (10 males, 10 females) who metDSM-IIIcriteria for obsessive-compulsive disorder (OCD). Six patients (30%) showed an abnormal escape from dexamethasone suppression. DST suppressors vs. DST nonsuppressors showed no differences in age, rate of secondary depressive disorders, or scores on the Hamilton Rating Scale for Depression, the Minnesota Multiphasic Personality Inventory D scale, or OCD rating scales. Surprisingly, there was a trend for suppressors to have a stringer family history of depressive disorders, and for nonsuppressors to include an excess of male subjects. Moreover, there was a significant correlation between levels of cortisol before and after DST. In five of six nonsuppressors, both depressive symptoms and obsessive- compulsive behaviors showed a diminution in response to antidepressant therapy combined, in one case, with intensive behavior therapy. The relationships between OCD and endogenous depression, as well as the specificity of the DST, are discussed.
影响因子：
--
作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young
通讯作者：
B. Carroll;M. Feinberg;J. Greden;J. Tarika;A. Albala;R. Haskett;Norman McI. James;Z. Kronfol;N. Lohr;M. Steiner;Jean Paul de Vigne;E. Young