Clostridi-al oncolysis in man
Clostridi-al oncolysis in man
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DOI：
10.1016/0014-2964(67)90060-6
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发表时间：
1967-01-01
期刊：
影响因子：
8.4
通讯作者：
BRYANT, B.
中科院分区：
文献类型：
--
作者：
CAREY, R. W.;HOLLAND, J. F.;BRYANT, B.
丁酸梭菌的抗肿瘤活性在小鼠自发性腺癌和人类肿瘤中得到证实。在接受抗生素、皮质类固醇和电解质溶液治疗的梭菌溶瘤小鼠中，生存率得到改善。5名患者用1 × 10 ~（10）个C.丁酸。注射后4[长破折号]9天，血培养对此微生物呈阳性。3例患者的最大肿瘤发生溶瘤，但较小肿瘤未发生溶瘤。孢子治疗在1例受试者中产生了短暂的临床获益，在另1例受试者中对临床隐匿性肿瘤进行了溶瘤治疗，在第3例患者中进行了溶瘤治疗，但未得到临床认可。一个敏感和特异性的血凝试验，以测量患者和其他受试者的细菌抗体反应。在健康献血者和癌症患者中证实了低滴度的抗体。用孢子治疗的5名患者产生了大量滴度的抗体。3例溶瘤受试者的这些滴度高于2例肿瘤未能溶解的患者。梭菌溶瘤似乎与大肿瘤块的生理和生化特征有关，而不是与正常细胞和肿瘤细胞之间的定性差异或免疫细胞溶解有关，因此似乎临床有用性有限（如果有的话）。|| 摘要编辑：作者
Antineoplastic activity of Clostridium butyricum was demonstrated in spontaneous adenocarcinoma of mice and in tumors of man. Improved survival of mice occurred among those undergoing clostridial oncolysis when treated supportively with antibiotics, corticosteroids, and electrolyte solutions. Five patients were treated with 1 x l010 spores of C. butyricum. Blood cultures were positive for this microorganism for 4[long dash]9 days after injection. Oncolysis occurred in 3 patients in their largest tumors, but not in their smaller tumors. Spore treatment resulted in transient clinical benefit in 1 subject, oncolysis of a clinically occult tumor in another, and oncolysis in a third patient which was not clinically recognized. A sensitive and specific hemagglutination test was developed to measure the bacterial antibody response of the patients and other subjects. Antibodies in low titers were demonstrated in healthy blood donors and patients with cancer. The 5 patients treated with spores developed antibodies in substantial titers. These titers were higher in the 3 subjects with oncolysis than in the 2 patients whose tumors failed to lyse. Clostridial oncolysis appears to be related to the physiologic and biochemical characteristics of large tumor masses rather than to qualitative differences between normal and neoplastic cells or to immunologic cytolysis, and thus appears to be of limited, if any, clinical usefulness. || ABSTRACT AUTHORS: Authors