HIGH-INCIDENCE OF URINARY JC VIRUS EXCRETION IN NONIMMUNOSUPPRESSED OLDER PATIENTS
HIGH-INCIDENCE OF URINARY JC VIRUS EXCRETION IN NONIMMUNOSUPPRESSED OLDER PATIENTS
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DOI：
10.1093/infdis/161.6.1128
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发表时间：
1990-06-01
影响因子：
6.4
通讯作者：
YOGO, Y
中科院分区：
文献类型：
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作者：
KITAMURA, T;ASO, Y;YOGO, Y
对120例泌尿科门诊患者的尿液标本进行了多瘤病毒DNA的印迹杂交筛选。检测到的病毒DNA经精细限制性内切酶分析鉴定为BK或JC。BK和JC病毒DNA分别为5例（4%）和35例（29%）。比较0-29岁、30-59岁和60-89岁三个年龄组的检出率。JC病毒DNA检出率随年龄增长而增加，60 ~ 89岁组最高（45%）。对于BK病毒DNA，检出率与年龄之间的相关性尚不清楚，因为检出率很低，尽管最高的检出率（9%）发生在最年长的人群中。为了证实老年患者尿液中多瘤病毒DNA的活跃排泄，我们对在内科诊所治疗的23例患者（60-90岁）的尿液样本进行了病毒DNA检测。BK和JC病毒DNA分别为2例（9%）和12例（52%）。这些结果表明，JC病毒在老年人中经常被重新激活。
Urine specimens from 120 patients attending urologic clinics were screened by blot hybridization for the presence of a polyomavirus DNA. Detected viral DNA was then identified as BK or JC by fine restriction enzyme analysis. BK and JC viral DNA was found in 5 (4%) and 35 (29%) patients, respectively. Detection rates were compared among three age groups: 0-29, 30-59, and 60-89 years. Detection of JC viral DNA increased with age and reached the highest value (45%) in the group aged 60-89 years. For BK viral DNA a correlation between detection and age was not clear because the rate of detection was low, although the highest rate (9%) occurred in the oldest group. To confirm the active urinary excretion of polyomavirus DNA in older patients, urine specimens from 23 patients (60-90 years) treated at an internal medicine clinic were examined for viral DNA. BK and JC viral DNA were in 2 (9%) and 12 patients (52%), respectively. These results suggest tht JC virus is frequently reactivated in older individuals.