Computerized measurement of negative symptoms in schizophrenia
Computerized measurement of negative symptoms in schizophrenia
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DOI：
10.1016/j.jpsychires.2007.08.008
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发表时间：
2008-08-01
影响因子：
4.8
通讯作者：
Docherty, Nancy M.
中科院分区：
文献类型：
--
作者：
Cohen, Alex S.;Alpert, Murray;Docherty, Nancy M.
准确测量阴性症状对于了解和治疗精神分裂症至关重要。然而，目前的测量策略依赖于主观症状评定量表，这往往具有心理测量学和实践上的局限性。对患者语音的计算机分析为评估阴性症状提供了一种复杂而客观的手段。本研究考察了广泛使用的声学和词汇分析软件测量平淡情绪、冷漠和快感缺失(通过积极情绪)的可行性和有效性。研究人员检查了这些指标与临床评定的阴性症状和社会功能的关系。对14例临床诊断为平淡情感的患者、46例无平淡情感的患者和19例健康对照的自然语音样本进行了采集和分析。基于计算机的音调和语速测量显著区分了扁平情感患者和对照组，而基于计算机的疏离和负面情绪测量显著区分了扁平和非扁平患者。计算机和临床对积极情绪/快感缺乏的测量都与功能障碍相对应。与基于症状量表的方法相比，计算机化的阴性症状评估方法具有许多优势。(C)2007爱思唯尔有限公司。保留所有权利。
Accurate measurement of negative symptoms is crucial for understanding and treating schizophrenia. However, current measurement strategies are reliant on subjective symptom rating scales, which often have psychometric and practical limitations. Computerized analysis of patients' speech offers a sophisticated and objective means of evaluating negative symptoms. The present study examined the feasibility and validity of using widely-avail able acoustic and lexical-analytic software to measure flat affect, alogia and anhedonia (via positive emotion). These measures were examined in their relationships to clinically-rated negative symptoms and social functioning. Natural speech samples were collected and analyzed for 14 patients with clinically-rated flat affect, 46 patients without flat affect and 19 healthy controls. The computer-based inflection and speech rate measures significantly discriminated patients with flat affect from controls, and the computer-based measure of alogia and negative emotion significantly discriminated the flat and nonflat patients. Both the computer and clinical measures of positive emotion/anhedonia corresponded to functioning impairments. The computerized method of assessing negative symptoms offered a number of advantages over the symptom scale-based approach. (C) 2007 Elsevier Ltd. All rights reserved.