A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer.
A Histone Acetylation Modulator Gene Signature for Classification and Prognosis of Breast Cancer.
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用于乳腺癌分类和预后的组蛋白乙酰化调节基因特征
DOI：
10.3390/curroncol28010091
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发表时间：
2021-02-17
期刊：
影响因子：
--
通讯作者：
Hu T
中科院分区：
文献类型：
--
作者：
Long M;Hou W;Liu Y;Hu T
组蛋白乙酰化调节剂有望成为乳腺癌治疗的表观遗传学靶点。在这项研究中，我们利用TCGA数据源，全面分析了组蛋白乙酰化调节基因在乳腺癌中的表达。由8个组蛋白乙酰化调节子(HAMs)组成的基因特征被发现对乳腺癌的分类和预后是有效的，特别是在HER2富集型和碱基样分子亚型中。这8个基因由两个组蛋白乙酰化编写器(GTF3C4和CLOCK)、两个擦除器(HDAC2和SIRT7)和四个读取器(BRD4、BRD7、SP100和BRWD3)组成。组蛋白乙酰化写入基因和橡皮擦基因在两组中均有差异表达，提示组蛋白乙酰化水平与HER2富集型和基底样型乳腺癌的预后密切相关。
Regulators of histone acetylation are promising epigenetic targets for therapy in breast cancer. In this study, we comprehensively analyzed the expression of histone acetylation modulator genes in breast cancer using TCGA data sources. A gene signature composed of eight histone acetylation modulators (HAMs) was found to be effective for the classification and prognosis of breast cancers, especially in the HER2-enriched and basal-like molecular subtypes. The eight genes consist of two histone acetylation writers (GTF3C4 and CLOCK), two erasers (HDAC2 and SIRT7) and four readers (BRD4, BRD7, SP100, and BRWD3). Both histone acetylation writer genes and eraser genes were found to be differentially expressed between the two groups indicating a close relationship exists between overall histone acetylation level and prognosis of breast cancer in HER2-enriched and basal-like breast cancer.
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影响因子：
3.8
作者：
Müller BM;Jana L;Kasajima A;Lehmann A;Prinzler J;Budczies J;Winzer KJ;Dietel M;Weichert W;Denkert C
通讯作者：
Denkert C
HER3、p95HER2 和 HER2 蛋白表达水平定义了 HER2 阳性转移性乳腺癌的多种亚型。
影响因子：
3.8
作者：
Lipton, Allan;Goodman, Laurie;Leitzel, Kim;Cook, Jennifer;Sperinde, Jeff;Haddad, Mojgan;Koestler, Wolfgang J.;Huang, Weidong;Weidler, Jodi M.;Ali, Suhail;Newton, Alicia;Fuchs, Eva-Marie;Paquet, Agnes;Singer, Christian F.;Horvat, Reinhard;Jin, Xueguang;Banerjee, Joyee;Mukherjee, Ali;Tan, Yuping;Shi, Yining;Chenna, Ahmed;Larson, Jeff;Lie, Yolanda;Sherwood, Thomas;Petropoulos, Christos J.;Williams, Stephen;Winslow, John;Parry, Gordon;Bates, Michael
通讯作者：
Bates, Michael
影响因子：
14.9
作者：
Ritchie ME;Phipson B;Wu D;Hu Y;Law CW;Shi W;Smyth GK
通讯作者：
Smyth GK
影响因子：
14.9
作者：
Colaprico A;Silva TC;Olsen C;Garofano L;Cava C;Garolini D;Sabedot TS;Malta TM;Pagnotta SM;Castiglioni I;Ceccarelli M;Bontempi G;Noushmehr H
通讯作者：
Noushmehr H
影响因子：
16.6
作者：
Hu, Zhongyi;Zhou, Junzhi;Zhang, Lin
通讯作者：
Zhang, Lin