Susceptibility of Treponema pallidum to host-derived antimicrobial peptides
Susceptibility of Treponema pallidum to host-derived antimicrobial peptides
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DOI：
10.1016/j.peptides.2003.07.026
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发表时间：
2003-11-01
期刊：
影响因子：
3
通讯作者：
Shafer, WM
中科院分区：
文献类型：
--
作者：
Cox, DL;Sun, YC;Shafer, WM
LL-37对许多致病菌显示出强有力的广谱活性，是迄今为止在人类中发现的唯一抗菌肽。在这项研究中，我们检测了人LL-37和类似的兔源cap -18肽对梅毒梅毒螺旋体（Treponema pallidum）的抗菌活性。我们发现，这两种肽，以及人类LL-37的截短版本，包含其杀菌结构域，可以发挥快速，但盐敏感的抗菌活性对T. pallidum。合成的截断的ll -37衍生肽ws22 - n -酰胺可有效阻断兔白球绦虫模型的感染性。(C) 2003年Elsevier Inc.出版
LL-37 displays potent broad-spectrum activity against a number of pathogenic bacteria and is the only cathelicidin thus far identified in humans. In this study, we examined the capacity of human LL-37 and the similar CAP-18-derived peptide from rabbits to exert antimicrobial activity against the causative agent of syphilis, Treponema pallidum. We found that both peptides, as well as a truncated version of human LL-37 that contains its bactericidal domain, could exert rapid, but salt-sensitive antimicrobial activity against T. pallidum. Infectivity of T. pallidum in a rabbit model could effectively be blocked with the synthetic truncated LL-37-derived peptide WS22-N-amide. (C) 2003 Published by Elsevier Inc.