The Leicester Risk Assessment score for detecting undiagnosed Type 2 diabetes and impaired glucose regulation for use in a multiethnic UK setting
The Leicester Risk Assessment score for detecting undiagnosed Type 2 diabetes and impaired glucose regulation for use in a multiethnic UK setting
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DOI：
10.1111/j.1464-5491.2010.03037.x
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发表时间：
2010-08-01
影响因子：
3.5
通讯作者：
Davies, M. J.
中科院分区：
文献类型：
--
作者：
Gray, L. J.;Taub, N. A.;Davies, M. J.
目的风险评估评分识别血糖调节障碍和2型糖尿病的高危人群。到目前为止，还没有专门针对英国多民族人群开发和验证的由非专业人员完成的风险评估分数。方法：我们使用来自英国多种族筛查研究的6186名年龄在40-75岁之间的受试者的数据（73%的欧洲白人，22%的南亚人）。所有参与者都进行了75克口服葡萄糖耐量试验。我们开发了logistic回归模型，利用人体测量和自我报告问卷的数据预测当前的血糖调节受损（空腹血糖受损/糖耐量受损）或2型糖尿病。使用最佳拟合模型，我们开发了莱斯特风险评估评分。我们使用来自一项单独筛选研究的3171名年龄在40-75岁的受试者的数据对评分进行了外部验证。结果最终模型的组成部分是年龄、种族[欧洲白人与其他（主要是南亚人）]、性别、糖尿病一级家族史、降压治疗或高血压史、腰围和体重指数。取值范围是0 ~ 47。利用第二次筛选研究的数据验证该模型，得出接受者操作者特征曲线下的面积为72%（95%置信区间，69-74%）。切点16的敏感性为81%，特异性为45%。结论莱斯特风险评估评分可用于识别英国多民族人群中血糖调节障碍和2型糖尿病的高危人群。分数很简单（7道题），而且是非侵入性的。
P>AimsRisk assessment scores identify those at high risk of impaired glucose regulation and Type 2 diabetes mellitus. To date no risk assessment scores that can be completed by a lay person have been developed and validated specifically for multiethnic populations in the UK.MethodsWe used data on 6186 subjects aged 40-75 years from a multiethnic UK screening study (73% white European, 22% South Asian). All participants were given a 75 g oral glucose tolerance test. We developed logistic regression models for predicting current impaired glucose regulation (impaired fasting glycaemia/impaired glucose tolerance) or Type 2 diabetes mellitus using data from anthropometric measurements and self-reported questionnaires. Using the best-fitting model, we developed the Leicester Risk Assessment score. We externally validated the score using data from 3171 subjects aged 40-75 years from a separate screening study.ResultsThe components of the final model are age, ethnicity [white European vs. other (predominantly South Asian)], sex, first degree family history of diabetes, antihypertensive therapy or history of hypertension, waist circumference and body mass index. The score ranges from 0 to 47. Validating this model using the data from the second screening study gave an area under the receiver operator characteristic curve of 72% (95% confidence interval, 69-74%). A cut point of 16 had a sensitivity of 81% and a specificity of 45%.ConclusionsThe Leicester Risk Assessment score can be used to identify those at high risk of impaired glucose regulation and Type 2 diabetes mellitus in UK multiethnic populations. The score is simple (seven questions) and non-invasive.