Role of the stem cell niche in the pathogenesis of epithelial ovarian cancers.
Role of the stem cell niche in the pathogenesis of epithelial ovarian cancers.
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DOI：
10.4161/23723548.2014.963435
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发表时间：
2014-07
影响因子：
2.1
通讯作者：
Nikitin AY
中科院分区：
文献类型：
--
作者：
Flesken-Nikitin A;Odai-Afotey AA;Nikitin AY
卵巢癌是美国女性癌症相关死亡的第五大原因。最近广泛的上皮性卵巢癌(EOC)的基因组分析，特别是最常见和最致命的高级别浆液性卵巢癌，为了解这种恶性肿瘤特有的分子异常提供了重要的见解。然而，对所发现的像差的解释是复杂的，因为EOC的起源和进展机制仍然不确定。在这里，我们总结了目前关于EOC起源细胞的观点，并讨论了卵巢表面上皮易癌干细胞生态位的最新发现，这是EOC的主要可能来源之一。我们还概述了未来在研究干细胞生态位在卵巢癌发病机制中的作用方面的方向和挑战。
Ovarian cancer is the fifth leading cause of cancer-related deaths among women in the United States. Recent extensive genomic analyses of epithelial ovarian cancer (EOC), particularly the most common and deadly form of high-grade serous ovarian carcinoma, have provided important insights into the repertoire of molecular aberrations that are characteristic for this malignancy. However, interpretation of the discovered aberrations is complicated because the origin and mechanisms of progression of EOC remain uncertain. Here, we summarize current views on the cell of origin of EOC and discuss recent findings of a cancer-prone stem cell niche for ovarian surface epithelium, one of the major likely sources of EOC. We also outline future directions and challenges in studying the role of stem cell niches in EOC pathogenesis.