Specificity of P3 Event-Related Potential Reactivity to Alcohol Cues in Individuals Low in Alcohol Sensitivity
Specificity of P3 Event-Related Potential Reactivity to Alcohol Cues in Individuals Low in Alcohol Sensitivity
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DOI：
10.1037/a0017705
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发表时间：
2010-06-01
影响因子：
3.4
通讯作者：
Tragesser, Sarah L.
中科院分区：
文献类型：
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作者：
Bartholow, Bruce D.;Lust, Sarah A.;Tragesser, Sarah L.
最近使用事件相关电位（ERP）的研究表明，酒精敏感性低的个体对酒精提示的P3反应性增加（Bartholow，亨利，& Lust，2007）。目前的研究试图测试这种效应的特异性，包括其他唤醒线索除了酒精，并通过控制个性冲动的个体差异。47名自我报告酒精敏感度不同的参与者完成了一项视觉古怪任务，包括中性，唤起（色情和冒险相关）和饮料相关的图像，同时记录ERP。低敏感性的参与者表现出增加P3反应酒精线索相对于他们的高敏感性的同龄人。然而，P3振幅引起的所有其他目标没有不同的酒精敏感性水平的函数。冲动性和近期饮酒的差异并不能解释酒精线索反应的敏感性组差异。这些结果指出，酒精线索的具体动机显着性的酒精问题的风险，因为酒精敏感性低的个人，并建议P3反应酒精线索可能是一个新的内表型酒精使用障碍的风险。
Recent research using event-related potentials (ERPs) has shown that individuals low in alcohol sensitivity show increased P3 reactivity to alcohol cues (Bartholow, Henry, & Lust, 2007). The current research sought to test the specificity of this effect by including other arousing cues in addition to alcohol, and by controlling for individual differences in trait impulsivity. Forty-seven participants varying in self-reported alcohol sensitivity completed a visual oddball task including neutral, arousing (erotic and adventure-related), and beverage-related images while ERPs were recorded. Low-sensitivity participants showed increased P3 reactivity to alcohol cues relative to their high-sensitivity peers. However, P3 amplitude elicited by all other targets did not differ as a function of alcohol sensitivity levels. Differences in impulsivity and recent alcohol consumption did not account for sensitivity group differences in alcohol cue reactivity. These results point to the specific motivational salience of alcohol cues to individuals at risk for alcohol problems because of low alcohol sensitivity and suggest that P3 reactivity to alcohol cues could be a new endophenotype for alcohol use disorder risk.