Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double-blind, placebo-controlled trial
Blackcurrant seed oil for prevention of atopic dermatitis in newborns: a randomized, double-blind, placebo-controlled trial
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DOI：
10.1111/j.1365-2222.2010.03540.x
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发表时间：
2010-08-01
影响因子：
6.1
通讯作者：
Tahvonen, R.
中科院分区：
文献类型：
--
作者：
Linnamaa, P.;Savolainen, J.;Tahvonen, R.
背景目前特应性疾病发病率的增加与必需脂肪酸（EFA）摄入量的改变有关。黑加仑籽油（BCSO）的组成对应于EFA的推荐膳食摄入量，作为膳食补充剂，小剂量，目的探讨在孕妇膳食中添加BCSO对12月龄特应性疾病患病率的影响。或橄榄油作为安慰剂（162）。在妊娠第8 - 16周给予第一剂，并持续至母乳喂养停止，然后补充婴儿至2岁。特应性皮炎及其严重程度（SCORAD指数）进行了评估，血清总IgE测定和皮肤试验进行了3，12和24 months.Results的年龄是常见的（81.7%）在研究对象，使他们的婴儿与增加的特应性风险。在12个月龄时，BCSO组的异位性皮炎患病率显著低于橄榄油组（33.0% vs. 47.3%，P=0.035）。在12个月龄时，BCSO组的SCORAD也低于橄榄油组（P=0.035）。在24个月龄时，两组间异位性皮炎的患病率无显著差异（P=0.18）。结论膳食补充BCSO耐受性良好，可短暂降低异位性皮炎的患病率。因此，当在生命的早期阶段使用时，它可能是预防特应性症状的一种潜在工具。（注册号SRCTN 14869647，http://www.controlled-trials.com）
Background The present increased incidence of atopic diseases has been associated with an altered intake of essential fatty acids (EFAs). The composition of blackcurrant seed oil (BCSO) corresponds to the recommended dietary intake of EFAs, and as a dietary supplement could, in small doses, modify the imbalance of EFAs in an efficient way.Objective To assess the effect of dietary supplementation with BCSO on the prevalence of atopy at 12 months of age.Methods Three hundred and thirteen pregnant mothers were randomly assigned to receive BCSO (151) or olive oil as placebo (162). The first doses were administered at 8th-16th weeks of pregnancy and were continued until the cessation of breastfeeding, followed by supplementation to the infants until the age of 2 years. Atopic dermatitis and its severity (SCORAD index) were evaluated, serum total IgE was measured and skin tests were performed at the age of 3, 12 and 24 months.Results Parental atopy was common (81.7%) among study subjects, making them infants with increased atopy risk. There was a significantly lower prevalence of atopic dermatitis in the BCSO group than in the olive oil group at the age of 12 months (33.0% vs. 47.3%, P=0.035). SCORAD was also lower in the BCSO group than in the olive oil group at 12 months of age (P=0.035). No significant differences in the prevalence of atopic dermatitis were observed between the groups at the age of 24 months (P=0.18).Conclusion Dietary supplementation with BCSO was well tolerated and it transiently reduced the prevalence of atopic dermatitis. It could therefore be one potential tool in the prevention of atopic symptoms when used at an early stage of life. (Registration number SRCTN14869647, http://www.controlled-trials.com)