NON-INVASIVE CHARACTERIZATION OF RENAL-ARTERY BLOOD-FLOW
NON-INVASIVE CHARACTERIZATION OF RENAL-ARTERY BLOOD-FLOW
复制标题
DOI：
10.1038/ki.1981.171
复制
发表时间：
1981-01-01
影响因子：
19.6
通讯作者：
JAHNKE, RW
中科院分区：
文献类型：
--
作者：
GREENE, ER;VENTERS, MD;JAHNKE, RW
此前尚未报道过人体肾动脉血流变量的无创表征。使用经过体外校准的独特双频实时二维回波多普勒（复式扫描仪），计算了 16 名正常受试者（6 名女性）的肾动脉血流模式。收缩直径(Ds)、最大空间平均血流速度(Vmsa)和体积流速(.ovrhdot.Q)的计算平均值如下：4.5±。 0.6 毫米右，4.4 .+-。左 0.6 毫米； 67.6.+-. 9.4 厘米.cntdot。 s-1 右，69.6 .+-。 12.0 厘米.cntdot。 s-1 左；和403.+-。 127 毫升 .cntdot。分钟-1 右，395 .+-。 98 毫升 .cntdot。分别还剩 min-1。体表面积 (BSA) 与 Ds 和 ovrhdot.Q 的直接线性回归相关性具有统计学显着性（分别为 P < 0.01，r = 0.70；和 P < 0.01，r = 0.72）。在一项盲法前瞻性系列研究中，7 条血管造影正常的肾动脉中的 6 条通过正常的几何形状和血流速度模式无创性地识别出来。一根血管造影正常的动脉被错误地分类为轻度狭窄。通过血管造影记录的 11 条异常肾动脉通过其异常血流模式和/或几何形状进行非侵入性识别。显然，双频双工扫描与仔细的样本量控制和多普勒音频频谱/血流速度波形分析可用于表征正常和患病人类肾动脉中的血流变量。
Noninvasive characterization of renal artery blood flow variables in the human was not previously reported. Using a unique dual-frequency real-time 2-dimensional echo Doppler (Duplex scanner) that was calibrated in vitro, renal artery blood flow patterns were calculated in 16 normal subjects (6 females). Calculated mean values of systolic diameter (Ds), maximal spatial average blood velocity (Vmsa) and volume flow rate (.ovrhdot.Q) were as follows: 4.5 .+-. 0.6 mm right, 4.4 .+-. 0.6 mm left; 67.6 .+-. 9.4 cm .cntdot. s-1 right, 69.6 .+-. 12.0 cm .cntdot. s-1 left; and 403 .+-. 127 ml .cntdot. min-1 right, 395 .+-. 98 ml .cntdot. min-1 left, respectively. Direct linear regression correlation of body surface area (BSA) with Ds and .ovrhdot.Q were statistically significant (P < 0.01, r = 0.70; and P < 0.01, r = 0.72, respectively). In a blind prospective series, 6 of 7 angiographically normal renal arteries were noninvasively identified by normal geometry and blood velocity patterns. One angiographically normal artery was incorrectly classified as mildly stenotic. Eleven angiographically documented abnormal renal arteries were noninvasively identified by their abnormal blood flow patterns and/or geometry. Apparently, dual-frequency Duplex scanning with careful sample volume control and Doppler audio spectra/blood velocity waveform analysis can be used to characterize blood flow variables in normal and diseased human renal arteries.