RECOVERY FROM STEROID-INDUCED OSTEOPOROSIS
RECOVERY FROM STEROID-INDUCED OSTEOPOROSIS
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DOI：
10.7326/0003-4819-107-2-319
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发表时间：
1987-09-01
影响因子：
39.2
通讯作者：
HUQ, NL
中科院分区：
文献类型：
--
作者：
POCOCK, NA;EISMAN, JA;HUQ, NL
激素性骨质疏松症是库欣综合征和长期使用外源性皮质类固醇的主要并发症，其可逆性尚未有很好的文献记载。采用双光子骨密度仪对2例治疗成功的库欣综合征患者进行腰椎和股骨颈的骨密度测定，并对其进行24个月的随访。我们的数据首次显示骨密度在恢复期显著增加(高达20%)。伴随的生化变化，特别是血清骨钙素水平的显著增加，证实了在恢复期发生了增强的骨形成。这些发现表明，至少在年轻人中，类固醇引起的骨质疏松症是可以逆转的。
The reversibility of steroid-induced osteoporosis, a major complication of Cushing syndrome and long-term use of exogenous corticosteroids, is not well documented. We measured the bone mineral density of lumbar vertebrae and the femoral neck by dual-photon absorptiometry and determined the biochemical variables of bone turnover in two patients successfully treated for Cushing syndrome who were followed for the next 24 months. Our data are the first to show marked increases in bone density (up to 20%) during the recovery period. The accompanying biochemical changes, particularly the marked increase in serum osteocalcin levels, confirm that enhanced bone formation occurred during the recovery phase. These findings suggest that steroid-induced osteoporosis can be reversed at least in young persons.