Motor cortex retains and reorients neural dynamics during motor imagery.
Motor cortex retains and reorients neural dynamics during motor imagery.
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运动皮层在运动想象过程中保留并重新定向神经动力学。
DOI：
10.1101/2023.01.17.524394
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发表时间：
2023
期刊：
影响因子：
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通讯作者：
Collinger,JenniferL
中科院分区：
文献类型：
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作者：
Dekleva,BrianM;Chowdhury,RaeedH;Batista,AaronP;Chase,StevenM;Yu,ByronM;Boninger,MichaelL;Collinger,JenniferL
运动皮层最突出的特征是它在运动执行过程中被激活，但当我们在没有实际运动输出的情况下仅仅想象运动时，它也会活跃。尽管经过了数十年的行为和影像学研究，但在隐蔽运动想象过程中，运动皮层的特定活动模式和时间动态与运动执行过程中的活动模式和时间动态之间的关系尚不清楚。在这里，我们记录了两名在不完全脊髓损伤后保留一些残余手腕功能的人在进行实际和想象的等距手腕伸展时，运动皮层的皮质内活动。我们发现，我们可以将总体活动分解为三个正交的子空间，其中一个子空间在动作和想象中都同样活跃，而其他子空间仅在单一任务类型（动作或想象）中活跃。尽管它们位于正交的神经维度上，但动作唯一子空间和图像唯一子空间包含了一组惊人相似的动态特征。我们的研究结果表明，在运动想象过程中，运动皮层通过将与运动输出和/或反馈相关的组件重新定向到一个独特的、输出为零的图像子空间，保持了与执行过程中相同的总体种群动态。
The most prominent characteristic of motor cortex is its activation during movement execution, but it is also active when we simply imagine movements in the absence of actual motor output. Despite decades of behavioural and imaging studies, it is unknown how the specific activity patterns and temporal dynamics in motor cortex during covert motor imagery relate to those during motor execution. Here we recorded intracortical activity from the motor cortex of two people who retain some residual wrist function following incomplete spinal cord injury as they performed both actual and imagined isometric wrist extensions. We found that we could decompose the population activity into three orthogonal subspaces, where one was similarly active during both action and imagery, and the others were active only during a single task type—action or imagery. Although they inhabited orthogonal neural dimensions, the action-unique and imagery-unique subspaces contained a strikingly similar set of dynamic features. Our results suggest that during motor imagery, motor cortex maintains the same overall population dynamics as during execution by reorienting the components related to motor output and/or feedback into a unique, output-null imagery subspace.